Literature DB >> 16112582

Synthesis and biological evaluation of polyhydroxycurcuminoids.

Somepalli Venkateswarlu1, Marellapudi S Ramachandra, Gottumukkala V Subbaraju.   

Abstract

A series of curcumin analogs (1-3, 5a-5t) was synthesized through the condensation of appropriately protected hydroxybenzaldehydes with acetylacetone, followed by deprotection. The antioxidant activity of these analogs was determined by superoxide free radical nitroblue tetrazolium and DPPH free radical scavenging methods and the polyhydroxycurcuminoids (5l-5s) displayed excellent antioxidant activity. These analogs showed cytotoxicity to lymphocytes and promising tumor-reducing activity on Dalton's lymphoma ascites tumor cells.

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Year:  2005        PMID： 16112582     DOI： 10.1016/j.bmc.2005.06.050

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  20 in total

1.  Identification of new biologically active synthetic molecules: comparative experimental and theoretical studies on the structure-antioxidant activity relationship of cyclic 1,3-ketoamides.

Authors:  Riad Mustapha Kerbadou; Ratiba Hadjadj Aoul; Aouicha Benmaati; Assya Taleb; Salih Hacini; Hadjira Habib Zahmani
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2.  Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25-35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2.

Authors:  Decha Pinkaew; Chatchawan Changtam; Chainarong Tocharus; Piyarat Govitrapong; Pichaya Jumnongprakhon; Apichart Suksamrarn; Jiraporn Tocharus
Journal:  Neurotox Res       Date:  2015-09-10       Impact factor: 3.911

3.  In silico screening of epidermal growth factor receptor (EGFR) in the tyrosine kinase domain through a medicinal plant compound database.

Authors:  Orathai Sawatdichaikul; Supa Hannongbua; Chak Sangma; Peter Wolschann; Kiattawee Choowongkomon
Journal:  J Mol Model       Date:  2011-06-29       Impact factor: 1.810

Review 4.  Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review.

Authors:  Augustine Amalraj; Anitha Pius; Sreerag Gopi; Sreeraj Gopi
Journal:  J Tradit Complement Med       Date:  2016-06-15

5.  Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells.

Authors:  Jiraporn Tocharus; Sataporn Jamsuwan; Chainarong Tocharus; Chatchawan Changtam; Apichart Suksamrarn
Journal:  J Nat Med       Date:  2011-10-13       Impact factor: 2.343

6.  Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.

Authors:  Jayaraj Ravindran; Gottumukkala V Subbaraju; Modukuri V Ramani; Bokyung Sung; Bharat B Aggarwal
Journal:  Biochem Pharmacol       Date:  2010-02-04       Impact factor: 5.858

7.  The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

Authors:  Matthew A Bill; James R Fuchs; Chenglong Li; Jennifer Yui; Courtney Bakan; Don M Benson; Eric B Schwartz; Dalia Abdelhamid; Jiayuh Lin; Dale G Hoyt; Stacey L Fossey; Gregory S Young; William E Carson; Pui-Kai Li; Gregory B Lesinski
Journal:  Mol Cancer       Date:  2010-06-25       Impact factor: 27.401

8.  Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities.

Authors:  Michael Deters; Heiko Knochenwefel; Daniel Lindhorst; Therese Koal; Hartmut H Meyer; Wolfram Hänsel; Klaus Resch; Volkhard Kaever
Journal:  Pharm Res       Date:  2008-04-22       Impact factor: 4.200

9.  Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines.

Authors:  Matthew A Bill; Courtney Bakan; Don M Benson; James Fuchs; Gregory Young; Gregory B Lesinski
Journal:  Mol Cancer Ther       Date:  2009-09-01       Impact factor: 6.261

10.  Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.

Authors:  Chongzhao Ran; Wei Zhao; Robert D Moir; Anna Moore
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240
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