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Literature DB >> 16112577

Cell individuality: the bistability of competence development.

Abstract

Heterogeneous development of competence among cells of the bacterium Bacillus subtilis provides an appealing model of cell individuality, an area that is currently attracting considerable research interest. Under appropriate conditions, only a fraction of cells in an isogenic culture become competent for transformation. Two experimental studies have now pinpointed the same auto-stimulatory feedback loop of gene expression as the principal requirement for the establishment of this 'bistable' response.

Entities: Species

Mesh：

Year: 2005 PMID： 16112577 DOI： 10.1016/j.tim.2005.08.006

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

12 in total

Cell individuality: the bistability of competence development.

1. Kinetics of genetic switching into the state of bacterial competence.

2. Subpopulation-specific transcriptome analysis of competence-stimulating-peptide-induced Streptococcus mutans.

3. Analysis of stochastic strategies in bacterial competence: a master equation approach.

Review 4. Molecular control of bacterial death and lysis.

5. To grow is not enough: impact of noise on cell environmental response and fitness.

6. Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations.

7. Emergence of switch-like behavior in a large family of simple biochemical networks.

8. Optimality principles in the regulation of metabolic networks.

9. The capacity for multistability in small gene regulatory networks.

10. The origin of phenotypic heterogeneity in a clonal cell population in vitro.