Literature DB >> 16112409

The role of adrenomedullin in angiogenesis.

Domenico Ribatti1, Beatrice Nico, Raffaella Spinazzi, Angelo Vacca, Gastone G Nussdorfer.   

Abstract

Adrenomedullin (AM) is a 52 amino acid peptide originally isolated from human pheochromocytoma. It was initially demonstrated to have profound effects in vascular cell biology, since AM protects endothelial cells from apoptosis, promotes angiogenesis and affects vascular tone and permeability. This review article summarizes the literature data concerning the relationship between AM and angiogenesis and describes the relationship between vascular endothelial growth factor, hypoxia and AM and tumor angiogenesis. Finally, the role of AM as a potential target of antiangiogenic therapy is discussed.

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Year:  2005        PMID： 16112409     DOI： 10.1016/j.peptides.2005.02.017

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  22 in total

1.  Phosphorylation of cAMP response element binding protein (CREB) as a marker of hypoxia in pituitary adenoma.

Authors:  Daijiro Morimoto; Daizo Yoshida; Masahiro Noha; Masanori Suzuki; R Yoshiyuki Osamura; Akira Teramoto
Journal:  J Neurooncol       Date:  2006-04-06       Impact factor: 4.130

2.  Adrenomedullin gene dosage correlates with tumor and lymph node lymphangiogenesis.

Authors:  Natalie O Karpinich; Daniel O Kechele; Scott T Espenschied; Helen H Willcockson; Yuri Fedoriw; Kathleen M Caron
Journal:  FASEB J       Date:  2012-10-25       Impact factor: 5.191

3.  Plasma adrenomedullin level in Egyptian children and adolescents with type 1 diabetes mellitus: relationship to microvascular complications.

Authors:  Safinaz A El-Habashy; Randa M Matter; Eman S El-Hadidi; Hala R Afifi
Journal:  Diabetol Metab Syndr       Date:  2010-02-10       Impact factor: 3.320

4.  RNA interference targeting adrenomedullin induces apoptosis and reduces the growth of human bladder urothelial cell carcinoma.

Authors:  Ai-guang Liu; Xi-zhong Zhang; Fen-bao Li; Yong-li Zhao; Ying-chang Guo; Rui-min Yang
Journal:  Med Oncol       Date:  2013-05-29       Impact factor: 3.064

5.  Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy.

Authors:  Jan J Blom; Thomas J Giove; Tara L Favazza; James D Akula; William D Eldred
Journal:  J Ocul Biol Dis Infor       Date:  2012-01-12

6.  Adrenomedullin signaling is necessary for murine lymphatic vascular development.

Authors:  Kimberly L Fritz-Six; William P Dunworth; Manyu Li; Kathleen M Caron
Journal:  J Clin Invest       Date:  2008-01       Impact factor: 14.808

7.  Adrenomedullin is a therapeutic target in colorectal cancer.

Authors:  Liangjing Wang; Manish Gala; Masayoshi Yamamoto; Maria S Pino; Hirotoshi Kikuchi; Daniel S Shue; Senji Shirasawa; Thomas R Austin; Maureen P Lynch; Bo R Rueda; Lawrence R Zukerberg; Daniel C Chung
Journal:  Int J Cancer       Date:  2013-11-07       Impact factor: 7.396

8.  Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab.

Authors:  Anne M Schultheis; Georg Lurje; Katrin E Rhodes; Wu Zhang; Dongyun Yang; Agustin A Garcia; Robert Morgan; David Gandara; Sidney Scudder; Amit Oza; Hal Hirte; Gini Fleming; Lynda Roman; Heinz-Josef Lenz
Journal:  Clin Cancer Res       Date:  2008-11-15       Impact factor: 12.531

9.  Effects of Controlled Cortical Impact on the Mouse Brain Vasculome.

Authors:  Shuzhen Guo; Josephine Lok; Song Zhao; Wendy Leung; Angel T Som; Kazuhide Hayakawa; Qingzhi Wang; Changhong Xing; Xiaoying Wang; Xunming Ji; Yiming Zhou; Eng H Lo
Journal:  J Neurotrauma       Date:  2016-02-12       Impact factor: 5.269

Review 10.  Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: a review of experimental studies.

Authors:  Mingyuan Wu; Bengt Linderoth; Robert D Foreman
Journal:  Auton Neurosci       Date:  2008-02-29       Impact factor: 3.145
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