Literature DB >> 16112398

Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus.

Pierre Poitras1, William J Polvino, Bernard Rocheleau.   

Abstract

We aimed to confirm the gastrokinetic effect of ghrelin analog, RC-1139, in the presence of opiates. Gastric emptying was verified in rats by counting stomach residue 15 min after gavage of methylcellulose. Normal rats: RC-1139 (0, 0.25, 1.0, 2.5 mg/kg i.v.) decreased methylcellulose left in stomach (47, 36, 12, 10% of ingested solution). Post-operative ileus (post-op. ileus) ileus: gastric residue decreased from 88 to 66, 53, 51% with RC-1139 0, 1.0, 2.5, 10 mg/kg. Morphine in post-op. ileus: gastroparesis was corrected at 10 mg/kg (54%). Ghrelin analog RC-1139 is a potent gastrokinetic in rat; it reversed gastric post-op. ileus, even in the presence of opiates.

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Year:  2005        PMID： 16112398     DOI： 10.1016/j.peptides.2005.02.010

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  14 in total

1.  Central administration of pan-somatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in rats.

Authors:  A Stengel; M Goebel-Stengel; L Wang; A Luckey; E Hu; J Rivier; Y Taché
Journal:  Neurogastroenterol Motil       Date:  2011-05-13       Impact factor: 3.598

2.  Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.

Authors:  Andreas Stengel; Miriam Goebel; Andrew Luckey; Pu-Qing Yuan; Lixin Wang; Yvette Taché
Journal:  Peptides       Date:  2010-09-15       Impact factor: 3.750

Review 3.  Current and potential roles of ghrelin in clinical practice.

Authors:  G Angelidis; V Valotassiou; P Georgoulias
Journal:  J Endocrinol Invest       Date:  2010-12       Impact factor: 4.256

Review 4.  The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanism.

Authors:  Mark D DeBoer
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

5.  Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus.

Authors:  Kalina Venkova; Graeme Fraser; Hamid R Hoveyda; Beverley Greenwood-Van Meerveld
Journal:  Dig Dis Sci       Date:  2007-04-10       Impact factor: 3.199

Review 6.  Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications.

Authors:  Andreas Stengel; Lixin Wang; Yvette Taché
Journal:  Peptides       Date:  2011-07-12       Impact factor: 3.750

7.  Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract.

Authors:  A K Bassil; Y Häglund; J Brown; T Rudholm; P M Hellström; E Näslund; K Lee; G J Sanger
Journal:  Br J Pharmacol       Date:  2006-11-27       Impact factor: 8.739

8.  Integrating GHS into the Ghrelin System.

Authors:  Johannes D Veldhuis; Cyril Y Bowers
Journal:  Int J Pept       Date:  2010-03-18

9.  The prokinetic face of ghrelin.

Authors:  Hanaa S Sallam; Jiande D Z Chen
Journal:  Int J Pept       Date:  2010-02-10

Review 10.  Brain peptides and the modulation of postoperative gastric ileus.

Authors:  Andreas Stengel; Yvette Taché
Journal:  Curr Opin Pharmacol       Date:  2014-07-09       Impact factor: 5.547
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