OBJECTIVE:Hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated for patients with minimal residual or no residual disease after primary surgery and chemotherapy for stage III ovarian carcinoma. The use of operative laparoscopy to perform peritonectomy and HIPEC is reported. METHODS:Five adult pigs were used. The placement of trocars in the four quadrants was planned in order to complete a total peritonectomy and then to place the HIPEC drains. The umbilical trocar was then replaced manually by the surgeon through a Lapdisc to manipulate the bowel loops. The abdominal cavity was filled with heated saline (43 degrees C), and the pumps were activated for 30 min. RESULTS: The procedure was successfully completed with an adequate intraabdominal temperature and distribution. CONCLUSION: These preliminary data suggest the technical feasibility of the laparoscopic approach for HIPEC, in an animal model without carcinomatosis. Our ongoing research is designed to gather pharmacokinetic data in an experimental controlled randomized fashion to compare a laparoscopic to a laparotomy approach on the same model.
RCT Entities:
OBJECTIVE: Hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated for patients with minimal residual or no residual disease after primary surgery and chemotherapy for stage III ovarian carcinoma. The use of operative laparoscopy to perform peritonectomy and HIPEC is reported. METHODS: Five adult pigs were used. The placement of trocars in the four quadrants was planned in order to complete a total peritonectomy and then to place the HIPEC drains. The umbilical trocar was then replaced manually by the surgeon through a Lapdisc to manipulate the bowel loops. The abdominal cavity was filled with heated saline (43 degrees C), and the pumps were activated for 30 min. RESULTS: The procedure was successfully completed with an adequate intraabdominal temperature and distribution. CONCLUSION: These preliminary data suggest the technical feasibility of the laparoscopic approach for HIPEC, in an animal model without carcinomatosis. Our ongoing research is designed to gather pharmacokinetic data in an experimental controlled randomized fashion to compare a laparoscopic to a laparotomy approach on the same model.
Authors: Stefano Cianci; Giuseppe Vizzielli; Anna Fagotti; Fabio Pacelli; Andrea Di Giorgio; Alessandro Tropea; Antonio Biondi; Giovanni Scambia Journal: Updates Surg Date: 2018-06-25
Authors: A Arjona-Sanchez; J Esquivel; O Glehen; G Passot; K K Turaga; D Labow; S Rufian-Peña; R Morales; K van der Speeten Journal: Surg Endosc Date: 2018-07-12 Impact factor: 4.584
Authors: A Arjona-Sanchez; S Rufian-Peña; J M Sanchez-Hidalgo; A Casado-Adam; A Cosano-Alvarez; J Briceño-Delgado Journal: World J Surg Date: 2018-10 Impact factor: 3.352
Authors: Charlotte E L Klaver; Gijsbert D Musters; Willem A Bemelman; Cornelis J A Punt; Victor J Verwaal; Marcel G W Dijkgraaf; Arend G J Aalbers; Jarmila D W van der Bilt; Djamila Boerma; Andre J A Bremers; Jacobus W A Burger; Christianne J Buskens; Pauline Evers; Robert J van Ginkel; Wilhelmina M U van Grevenstein; Patrick H J Hemmer; Ignace H J T de Hingh; Laureen A Lammers; Barbara L van Leeuwen; Wilhelmus J H J Meijerink; Simon W Nienhuijs; Jolien Pon; Sandra A Radema; Bert van Ramshorst; Petur Snaebjornsson; Jurriaan B Tuynman; Elisabeth A Te Velde; Marinus J Wiezer; Johannes H W de Wilt; Pieter J Tanis Journal: BMC Cancer Date: 2015-05-24 Impact factor: 4.430