| Literature DB >> 16111887 |
Brian E Fink1, Gregory D Vite, Harold Mastalerz, John F Kadow, Soong-Hoon Kim, Kenneth J Leavitt, Karen Du, Donald Crews, Toomas Mitt, Tai W Wong, John T Hunt, Dolatrai M Vyas, John S Tokarski.
Abstract
A novel series of dual EGFR and HER2 inhibitors based on the pyrrolo[2,1-f][1,2,4]triazine nucleus is described. A general route toward their synthesis, which enables functionalization at multiple sites, has been developed. Biological evaluation in enzymatic and cell-based assays has identified a series of C-6 carbamates with potent biochemical and cellular activities.Entities:
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Year: 2005 PMID： 16111887 DOI： 10.1016/j.bmcl.2005.07.027
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823