| Literature DB >> 16111532 |
Sarah L White1, Larissa Belov, Nicole Barber, Philip D Hodgkin, Richard I Christopherson.
Abstract
1alpha,25-Dihydroxyvitamin D3 (1,25D3) induces HL60 cells to acquire a monocyte-like phenotype, while cells treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA) resemble macrophages. Using a microarray of 82 CD antibodies, 24 cluster of differentiation (CD) antigens were detected on HL60 cells. 1,25D3 induced the following antigens in decreasing order of the change: CD14, CD11c, CD11b, CD54, CD86, CD38 and CD66c, with repression of CD117, CD71, CD95, CD45 and CD64. TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64. The results presented provide a basis for monitoring differentiation therapy of myeloid leukaemias in patients.Entities:
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Year: 2005 PMID： 16111532 DOI： 10.1016/j.leukres.2005.02.012
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156