| Literature DB >> 1610956 |
J H Silver1, A P Hart, E C Williams, S L Cooper, S Charef, D Labarre, M Jozefowicz.
Abstract
Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.Entities:
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Year: 1992 PMID： 1610956 DOI： 10.1016/0142-9612(92)90037-o
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479