Literature DB >> 1610903

A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4).

S Hata1, T Tsukamoto, T Osumi.   

Abstract

Based on the published nucleotide sequence for rat hepatocyte nuclear factor 4 (HNF-4; Sladek, F.M., Zhong, W., Lai, E. and Darnell, J.E., Jr. (1990) Genes Dev. 4, 2353-2365), we have cloned a cDNA by means of polymerase chain reaction amplification of reverse-transcribed RNA (RT-PCR). Our clone contained an extra segment of 30 bp, which was not found in the previously reported clone, in the coding region near the C-terminus. Further RT-PCR analysis demonstrated that both isoforms of HNF-4 mRNA, i.e., with or without the 30 nucleotide segment, occur in rat liver and kidney, presumably by differential splicing.

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Year:  1992        PMID： 1610903     DOI： 10.1016/0167-4781(92)90080-j

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.

Authors:  F M Sladek; M D Ruse; L Nepomuceno; S M Huang; M R Stallcup
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Members of the nuclear factor 1 family and hepatocyte nuclear factor 4 bind to overlapping sequences of the L-II element on the rat pyruvate kinase L gene promoter and regulate its expression.

Authors:  K Yamada; T Tanaka; T Noguchi
Journal:  Biochem J       Date:  1997-06-15       Impact factor: 3.857

3.  Characterization of a dominant negative mutant form of the HNF-4 orphan receptor.

Authors:  D G Taylor; S Haubenwallner; T Leff
Journal:  Nucleic Acids Res       Date:  1996-08-01       Impact factor: 16.971

4.  The activation function 2 domain of hepatic nuclear factor 4 is regulated by a short C-terminal proline-rich repressor domain.

Authors:  V P Iyemere; N H Davies; G G Brownlee
Journal:  Nucleic Acids Res       Date:  1998-05-01       Impact factor: 16.971

5.  An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types.

Authors:  H Nakhei; A Lingott; I Lemm; G U Ryffel
Journal:  Nucleic Acids Res       Date:  1998-01-15       Impact factor: 16.971

6.  Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins.

Authors:  N Miura; K Tanaka
Journal:  Nucleic Acids Res       Date:  1993-08-11       Impact factor: 16.971

7.  Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.

Authors:  Kenji Daigo; Takeshi Kawamura; Yoshihiro Ohta; Riuko Ohashi; Satoshi Katayose; Toshiya Tanaka; Hiroyuki Aburatani; Makoto Naito; Tatsuhiko Kodama; Sigeo Ihara; Takao Hamakubo
Journal:  J Biol Chem       Date:  2010-11-03       Impact factor: 5.157

8.  Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats.

Authors:  Shuying Jiang; Toshiya Tanaka; Hiroko Iwanari; Hiromitsu Hotta; Hisahiko Yamashita; Junko Kumakura; Yuichiro Watanabe; Yasutoshi Uchiyama; Hiroyuki Aburatani; Takao Hamakubo; Tatsuhiko Kodama; Makoto Naito
Journal:  Nucl Recept       Date:  2003-08-08
  8 in total

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