AIM: To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of attained weight. RESEARCH DESIGN AND METHODS: Data were obtained from a longitudinal study of two cohorts: one of juvenile-onset obese (n = 248) and one of randomly selected control (n = 320) men, weighed at average ages of 20, 33, 44 and 51 years, respectively. RESULTS: For any given BMI, the risk of IGT was higher the greater the weight gain since age 20 (odds ratio of 1.10 per unit kg/m2 of BMI gain, confidence interval 1.03-1.17, P = 0.004), and weight gain during both the early and later ages contributed to the increased risk. Obese men, maintaining weight since age 20, had lower risk of IGT than non-obese men who became similarly obese by age 51. The risk of Type 2 diabetes increased by weight gain in early adult life, but not by more recent weight gain in the later periods, probably because of the development of Type 2 diabetes leading to weight loss. CONCLUSIONS: Independent of attained level of body weight in middle-aged men, weight gain is associated with increased risk of IGT, and is greater in those not overweight in childhood.
AIM: To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of attained weight. RESEARCH DESIGN AND METHODS: Data were obtained from a longitudinal study of two cohorts: one of juvenile-onset obese (n = 248) and one of randomly selected control (n = 320) men, weighed at average ages of 20, 33, 44 and 51 years, respectively. RESULTS: For any given BMI, the risk of IGT was higher the greater the weight gain since age 20 (odds ratio of 1.10 per unit kg/m2 of BMI gain, confidence interval 1.03-1.17, P = 0.004), and weight gain during both the early and later ages contributed to the increased risk. Obesemen, maintaining weight since age 20, had lower risk of IGT than non-obesemen who became similarly obese by age 51. The risk of Type 2 diabetes increased by weight gain in early adult life, but not by more recent weight gain in the later periods, probably because of the development of Type 2 diabetes leading to weight loss. CONCLUSIONS: Independent of attained level of body weight in middle-aged men, weight gain is associated with increased risk of IGT, and is greater in those not overweight in childhood.
Authors: Rong Jiang; Beverly H Brummett; Elizabeth R Hauser; Michael A Babyak; Ilene C Siegler; Abanish Singh; Arne Astrup; Oluf Pedersen; Torben Hansen; Claus Holst; Thorkild I A Sørensen; Redford B Williams Journal: Biol Psychol Date: 2013-02-19 Impact factor: 3.251
Authors: Sofia I Iqbal Kring; John Barefoot; Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Redford B Williams; Thorkild I A Sørensen Journal: PLoS One Date: 2011-01-19 Impact factor: 3.240
Authors: Esther Zimmermann; Kristin Skogstrand; David M Hougaard; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen; Tine Jess Journal: PLoS One Date: 2011-01-05 Impact factor: 3.240
Authors: Rachel M Freathy; Gbenga R Kazeem; Richard W Morris; Paul C D Johnson; Lavinia Paternoster; Shah Ebrahim; Andrew T Hattersley; Anita Hill; Aroon D Hingorani; Claus Holst; Barbara J Jefferis; Sofia I I Kring; Vincent Mooser; Sandosh Padmanabhan; Martin Preisig; Susan M Ring; Naveed Sattar; Mark N Upton; Peter Vollenweider; Gerard Waeber; Thorkild I A Sørensen; Timothy M Frayling; Graham Watt; Debbie A Lawlor; Peter H Whincup; Federica Tozzi; George Davey Smith; Marcus Munafò Journal: Int J Epidemiol Date: 2011-05-18 Impact factor: 7.196
Authors: Sofia I I Kring; Thomas Werge; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen Journal: PLoS One Date: 2009-08-19 Impact factor: 3.240