Literature DB >> 16107834

Adaptive immune responses in acute and chronic hepatitis C virus infection.

David G Bowen1, Christopher M Walker.   

Abstract

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

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Year:  2005        PMID： 16107834     DOI： 10.1038/nature04079

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  298 in total

1.  Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature.

Authors:  Michelle C Sabo; Vincent C Luca; Stuart C Ray; Jens Bukh; Daved H Fremont; Michael S Diamond
Journal:  Virology       Date:  2011-11-12       Impact factor: 3.616

2.  Peripheral immunization induces functional intrahepatic hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver.

Authors:  Krystle A Lang Kuhs; Roberta Toporovski; Arielle A Ginsberg; Abby L Olsen; Devon J Shedlock; Matthew P Morrow; Jian Yan; Rebecca G Wells; David B Weiner
Journal:  Hum Vaccin       Date:  2011-12-01

3.  Hepatocyte entry leads to degradation of autoreactive CD8 T cells.

Authors:  Volker Benseler; Alessandra Warren; Michelle Vo; Lauren E Holz; Szun S Tay; David G Le Couteur; Eamon Breen; Anthony C Allison; Nico van Rooijen; Claire McGuffog; Hans J Schlitt; David G Bowen; Geoffrey W McCaughan; Patrick Bertolino
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-20       Impact factor: 11.205

4.  Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins.

Authors:  Harel Dahari; Stephen M Feinstone; Marian E Major
Journal:  Gastroenterology       Date:  2010-06-02       Impact factor: 22.682

5.  Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species.

Authors:  Robert S Tacke; Hai-Chon Lee; Celeste Goh; Jeremy Courtney; Stephen J Polyak; Hugo R Rosen; Young S Hahn
Journal:  Hepatology       Date:  2012-02       Impact factor: 17.425

6.  Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase.

Authors:  Shuanghu Liu; Cassie A Nelson; Li Xiao; Ling Lu; Punit P Seth; Darrell R Davis; Curt H Hagedorn
Journal:  Antiviral Res       Date:  2010-11-12       Impact factor: 5.970

7.  Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.

Authors:  Dennis J Hartigan-O'Connor; Din Lin; James C Ryan; Valentina A Shvachko; Myrna L Cozen; Mark R Segal; Norah A Terrault; Lewis L Lanier; M Michele Manos; Joseph M McCune
Journal:  J Infect Dis       Date:  2013-12-10       Impact factor: 5.226

Review 8.  Chemokines in the immunopathogenesis of hepatitis C infection.

Authors:  Mathis Heydtmann; David H Adams
Journal:  Hepatology       Date:  2009-02       Impact factor: 17.425

9.  Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: an Egyptian study.

Authors:  Hanan Fouad; Maissa Saeed El Raziky; Rasha Ahmed Abdel Aziz; Dina Sabry; Ghada Mahmoud Abdel Aziz; Manal Ewais; Ahmed Reda Sayed
Journal:  World J Gastroenterol       Date:  2013-11-21       Impact factor: 5.742

10.  Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein.

Authors:  Zhenyong Keck; Wenyan Wang; Yong Wang; Patrick Lau; Thomas H R Carlsen; Jannick Prentoe; Jinming Xia; Arvind H Patel; Jens Bukh; Steven K H Foung
Journal:  J Virol       Date:  2012-10-24       Impact factor: 5.103
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