Literature DB >> 16107196

Anti-MRSA agents: under investigation, in the exploratory phase and clinically available.

André Bryskier1.   

Abstract

Staphylococcal infections are difficult to treat due to the rapid emergence of methicillin-resistant staphylococci and, unfortunately, vancomycin-intermediate or -resistant staphylococci. Numerous alternative treatments are urgently required. In this special report, intensive research of new molecules is highlighted--in known antibacterial families and new medicinal chemical entities.

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Year:  2005        PMID： 16107196     DOI： 10.1586/14787210.3.4.505

Source DB:  PubMed          Journal:  Expert Rev Anti Infect Ther        ISSN： 1478-7210            Impact factor:   5.091


  4 in total

1.  New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.

Authors:  Weixing Zhu; Jörg Haupenthal; Matthias Groh; Michelle Fountain; Rolf W Hartmann
Journal:  Antimicrob Agents Chemother       Date:  2014-05-12       Impact factor: 5.191

2.  Probability of target attainment for ceftobiprole as derived from a population pharmacokinetic analysis of 150 subjects.

Authors:  Thomas P Lodise; Rienk Pypstra; James B Kahn; Bindu P Murthy; Hui C Kimko; Karen Bush; Gary J Noel; George L Drusano
Journal:  Antimicrob Agents Chemother       Date:  2007-03-26       Impact factor: 5.191

3.  Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.

Authors:  Sophie M Lehar; Thomas Pillow; Min Xu; Leanna Staben; Kimberly K Kajihara; Richard Vandlen; Laura DePalatis; Helga Raab; Wouter L Hazenbos; J Hiroshi Morisaki; Janice Kim; Summer Park; Martine Darwish; Byoung-Chul Lee; Hilda Hernandez; Kelly M Loyet; Patrick Lupardus; Rina Fong; Donghong Yan; Cecile Chalouni; Elizabeth Luis; Yana Khalfin; Emile Plise; Jonathan Cheong; Joseph P Lyssikatos; Magnus Strandh; Klaus Koefoed; Peter S Andersen; John A Flygare; Man Wah Tan; Eric J Brown; Sanjeev Mariathasan
Journal:  Nature       Date:  2015-11-04       Impact factor: 49.962

4.  "Metaphilic" Cell-Penetrating Polypeptide-Vancomycin Conjugate Efficiently Eradicates Intracellular Bacteria via a Dual Mechanism.

Authors:  Yunjiang Jiang; Ming Han; Yang Bo; Yujun Feng; Wenming Li; Jason Ren Wu; Ziyuan Song; Zihao Zhao; Zhengzhong Tan; Yingying Chen; Tianrui Xue; Zihuan Fu; Shanny Hsuan Kuo; Gee W Lau; Erik Luijten; Jianjun Cheng
Journal:  ACS Cent Sci       Date:  2020-12-03       Impact factor: 14.553
  4 in total

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