Literature DB >> 16107136

Farnesoid X receptor: from structure to potential clinical applications.

Roberto Pellicciari1, Gabriele Costantino, Stefano Fiorucci.   

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Year:  2005        PMID: 16107136     DOI: 10.1021/jm0582221

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  27 in total

1.  Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.

Authors:  Julia Yue Cui; Lauren M Aleksunes; Yuji Tanaka; Zidong Donna Fu; Ying Guo; Grace Liejun Guo; Hong Lu; Xiao-Bo Zhong; Curtis D Klaassen
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-01-19       Impact factor: 4.052

2.  Blinded evaluation of farnesoid X receptor (FXR) ligands binding using molecular docking and free energy calculations.

Authors:  Edithe Selwa; Eddy Elisée; Agustin Zavala; Bogdan I Iorga
Journal:  J Comput Aided Mol Des       Date:  2017-09-02       Impact factor: 3.686

3.  Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.

Authors:  Xian Pan; Yoon-Kwang Lee; Hyunyoung Jeong
Journal:  Drug Metab Dispos       Date:  2015-04-29       Impact factor: 3.922

4.  Synthesis and Biological Evaluation of a Series of Bile Acid Derivatives as FXR Agonists for Treatment of NASH.

Authors:  Hualing Xiao; Peng Li; Xiaolin Li; Haiying He; Jianhua Wang; Fengxun Guo; Jiliang Zhang; Luxia Wei; Hongmei Zhang; Yueyuan Shi; Lijuan Hou; Liang Shen; Zhengxia Chen; Chunyan Du; Shouliang Fu; Pengtao Zhang; Fei Hao; Ping Wang; Deming Xu; Wei Liang; Xin Tian; Aiming Zhang; Xingdong Cheng; Ling Yang; Xiangjian Wang; Xiquan Zhang; Jian Li; Shuhui Chen
Journal:  ACS Med Chem Lett       Date:  2017-10-31       Impact factor: 4.345

5.  Structural requirements of the human sodium-dependent bile acid transporter (hASBT): role of 3- and 7-OH moieties on binding and translocation of bile acids.

Authors:  Pablo M González; Carlos F Lagos; Weslyn C Ward; James E Polli
Journal:  Mol Pharm       Date:  2013-12-26       Impact factor: 4.939

6.  Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Authors:  Donna D Yu; Wenwei Lin; Barry M Forman; Taosheng Chen
Journal:  Bioorg Med Chem       Date:  2014-04-16       Impact factor: 3.641

Review 7.  Primary sclerosing cholangitis.

Authors:  Marina G Silveira; Keith D Lindor
Journal:  Can J Gastroenterol       Date:  2008-08       Impact factor: 3.522

8.  Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.

Authors:  Donna D Yu; Wenwei Lin; Taosheng Chen; Barry M Forman
Journal:  Bioorg Med Chem       Date:  2013-05-07       Impact factor: 3.641

Review 9.  Endocrine functions of bile acids.

Authors:  Sander M Houten; Mitsuhiro Watanabe; Johan Auwerx
Journal:  EMBO J       Date:  2006-03-16       Impact factor: 11.598

Review 10.  Nuclear receptors as therapeutic targets in cholestatic liver diseases.

Authors:  Gernot Zollner; Michael Trauner
Journal:  Br J Pharmacol       Date:  2009-01       Impact factor: 8.739

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