Literature DB >> 16106080

Immune regulation of viral infection and vice versa.

Herbert W Virgin1.   

Abstract

In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding acute and chronic diseases caused by viruses. Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16106080     DOI： 10.1385/IR:32:1-3:293

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  115 in total

1.  Pathogenesis of acute and persistent murine herpesvirus infection in mice.

Authors:  J Rajcáni; D Blaskovic; J Svobodová; F Ciampor; D Hucková; D Staneková
Journal:  Acta Virol       Date:  1985-01       Impact factor: 1.162

2.  Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

Authors:  S Shresta; T A Graubert; D A Thomas; S Z Raptis; T J Ley
Journal:  Immunity       Date:  1999-05       Impact factor: 31.745

3.  Murine gammaherpesvirus 68 encodes a functional regulator of complement activation.

Authors:  S B Kapadia; H Molina; V van Berkel; S H Speck; H W Virgin
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

4.  Physical association of the K3 protein of gamma-2 herpesvirus 68 with major histocompatibility complex class I molecules with impaired peptide and beta(2)-microglobulin assembly.

Authors:  Y Y Lawrence Yu; Michael R Harris; Lonnie Lybarger; Lisa A Kimpler; Nancy B Myers; Herbert W Virgin; Ted H Hansen
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

5.  Mucosal and parenteral vaccination against acute and latent murine cytomegalovirus (MCMV) infection by using an attenuated MCMV mutant.

Authors:  M R MacDonald; X Y Li; R M Stenberg; A E Campbell; H W Virgin
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

6.  Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells.

Authors:  S Ehtisham; N P Sunil-Chandra; A A Nash
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

7.  Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice.

Authors:  Gabrielle T Belz; Haiyan Liu; Samita Andreansky; Peter C Doherty; Philip G Stevenson
Journal:  J Gen Virol       Date:  2003-02       Impact factor: 3.891

8.  Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes.

Authors:  Sofia Marques; Stacey Efstathiou; K G Smith; Matthias Haury; J Pedro Simas
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

9.  Lung epithelial cells are a major site of murine gammaherpesvirus persistence.

Authors:  J P Stewart; E J Usherwood; A Ross; H Dyson; T Nash
Journal:  J Exp Med       Date:  1998-06-15       Impact factor: 14.307

10.  In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.

Authors:  M M Simon; M Hausmann; T Tran; K Ebnet; J Tschopp; R ThaHla; A Müllbacher
Journal:  J Exp Med       Date:  1997-11-17       Impact factor: 14.307
View more
  8 in total

1.  Dendritic cells loaded with tumor B cells elicit broad immunity against murine gammaherpesvirus 68 but fail to prevent long-term latency.

Authors:  Janet Weslow-Schmidt; Fang Ye; Stephanie S Cush; Kathleen A Stuller; Marcia A Blackman; Emilio Flaño
Journal:  J Virol       Date:  2010-06-30       Impact factor: 5.103

2.  Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations.

Authors:  Kathleen A Stuller; Stephanie S Cush; Emilio Flaño
Journal:  J Immunol       Date:  2010-03-05       Impact factor: 5.422

3.  Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus.

Authors:  Eric J Yager; In-Jeong Kim; Michael L Freeman; Kathleen G Lanzer; Claire E Burkum; Tres Cookenham; David L Woodland; Marcia A Blackman
Journal:  Immun Ageing       Date:  2010-02-02       Impact factor: 6.400

4.  Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection.

Authors:  Michael J Molloy; Weijun Zhang; Edward J Usherwood
Journal:  J Immunol       Date:  2009-04-15       Impact factor: 5.422

5.  Effects of acute and chronic murine norovirus infections on immune responses and recovery from Friend retrovirus infection.

Authors:  Christoph G Ammann; Ronald J Messer; Kimberly Varvel; Blair L Debuysscher; Rachel A Lacasse; Amelia K Pinto; Kim J Hasenkrug
Journal:  J Virol       Date:  2009-10-07       Impact factor: 5.103

6.  Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node.

Authors:  Eric Wong; Brian Montoya; Colby Stotesbury; Maria Ferez; Ren-Huan Xu; Luis J Sigal
Journal:  Cell Rep       Date:  2019-12-03       Impact factor: 9.423

7.  Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy.

Authors:  Eric B Wong; Brian Montoya; Maria Ferez; Colby Stotesbury; Luis J Sigal
Journal:  PLoS Pathog       Date:  2019-12-26       Impact factor: 6.823

Review 8.  The role of infectious agents in the pathogenesis of vasculitis.

Authors:  Nicolò Pipitone; Carlo Salvarani
Journal:  Best Pract Res Clin Rheumatol       Date:  2008-10       Impact factor: 4.098
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.