| Literature DB >> 1610565 |
M L Tsaur1, M Sheng, D H Lowenstein, Y N Jan, L Y Jan.
Abstract
K+ channels are major determinants of membrane excitability. Differences in neuronal excitability within the nervous system may arise from differential expression of K+ channel genes, regulated spatially in a cell type-specific manner, or temporally in response to neuronal activity. We have compared the distribution of mRNAs of three K+ channel genes, Kv1.1, Kv1.2, and Kv4.2 in rat brain, and examined activity-dependent changes following treatment with the convulsant drug pentylenetetrazole. Both regional and cell type-specific differences of K+ channel gene expression were found. In addition, seizure activity caused a reduction of Kv1.2 and Kv4.2 mRNAs in the dentate granule cells of the hippocampus, raising the possibility that K+ channel gene regulation may play a role in long-term neuronal plasticity.Entities:
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Year: 1992 PMID： 1610565 DOI： 10.1016/0896-6273(92)90127-y
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173