Literature DB >> 1610299

Activity of glutathione-S-transferase in rat liver and kidneys after administration of lead or cadmium.

F Planas-Bohne1, M Elizalde.   

Abstract

The influence of an acute dose of lead nitrate or cadmium chloride on the activity of glutathione-S-transferase (GST) was investigated in rats. CdCl2 (10 mumol/kg) did not influence the enzyme activity in either organ. In contrast Pb(NO3)2 (100 mumol/kg) caused a significant increase of GST activity in both organs. SDS polyacrylamide gel electrophoresis (SDS-PAGE) showed that in liver the activity enhancement is due mainly to the induction of the isoenzyme GST 7-7, while in the kidneys the activity of all the isoenzymes is increased.

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Year:  1992        PMID： 1610299     DOI： 10.1007/bf01973633

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  15 in total

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Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

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Authors:  W H Habig; M J Pabst; W B Jakoby
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3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

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4.  Decreased glutathione S-transferase activity in mice livers by acute treatment with lead, independent of alteration in glutathione content.

Authors:  K Nakagawa
Journal:  Toxicol Lett       Date:  1991-04       Impact factor: 4.372

5.  Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.

Authors:  A Columbano; G M Ledda-Columbano; P Coni; P Pani
Journal:  Carcinogenesis       Date:  1987-02       Impact factor: 4.944

6.  Induction of rat liver glutathione transferase subunit 7 by lead nitrate.

Authors:  C Di Ilio; A Aceto; A Columbano; G M Ledda-Columbano; G Federici
Journal:  Cancer Lett       Date:  1989-08       Impact factor: 8.679

7.  Influence of chelating agents on the distribution and excretion of cadmium in rats.

Authors:  F Planas-Bohne; M Lehmann
Journal:  Toxicol Appl Pharmacol       Date:  1983-03-15       Impact factor: 4.219

8.  Glutathione-S-transferase activity in human superficial transitional cell carcinoma of the bladder. Comparison with healthy controls.

Authors:  A Lafuente; M Giralt; I Cervello; F Pujol; J Mallol
Journal:  Cancer       Date:  1990-05-01       Impact factor: 6.860

9.  Induction of rat liver glutathione transferase isoenzyme 7-7 by lead nitrate.

Authors:  L Dock
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

10.  Glutathione S-transferase (placental) as a marker of transformation in the human cervix uteri: an immunohistochemical study.

Authors:  B J Randall; B Angus; R Akiba; A Hall; A R Cattan; S J Proctor; R A Jones; C H Horne
Journal:  Br J Cancer       Date:  1990-10       Impact factor: 7.640
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  2 in total

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2.  Differential combined effect of cadmium and nickel on hepatic and renal glutathione S-transferases of the guinea pig.

Authors:  M Iscan; T Coban; B C Eke
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