| Literature DB >> 16102824 |
Zhijian Xiao1, Meirong Zhang, Xuping Liu, Yue Zhang, Lin Yang, Yushu Hao.
Abstract
Balanced chromosomal translocations rarely occur in myelodysplastic syndromes (MDS). We describe here in three further Chinese patients with myelodysplastic syndromes (MDS) whose cytogenetic analysis showed t(1;3)(p36;q21). We detected the expression pattern of MEL1 and MEL1s in BM of two healthy subjects and the three patients, and found that the expression of MEL1s was overexpressed in MDS patients with t(1;3)(p36;q21). Our findings combined previous observations reported in literature support that MDS patients with t(1;3)(p36;q21) should be a new specific subset of MDS. Imbalance of a complete MEL1 message with a PR domain and a short MEL1 message lacking a PR domain (MEL1S) might be involved in the pathogenesis of these patients.Entities:
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Year: 2005 PMID： 16102824 DOI： 10.1016/j.leukres.2005.07.002
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156