| Literature DB >> 16102532 |
Claire L Palmer1, Wonil Lim, Peter G R Hastie, Marie Toward, Viktor I Korolchuk, Stephen A Burbidge, George Banting, Graham L Collingridge, John T R Isaac, Jeremy M Henley.
Abstract
It is not fully understood how NMDAR-dependent LTD causes Ca(2+)-dependent endocytosis of AMPARs. Here we show that the neuronal Ca(2+) sensor hippocalcin binds the beta2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunoprecipitate in a Ca(2+)-sensitive manner. Infusion of a truncated mutant of hippocalcin (HIP(2-72)) that lacks the Ca(2+) binding domains prevents synaptically evoked LTD but has no effect on LTP. These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.Entities:
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Year: 2005 PMID： 16102532 PMCID： PMC1563146 DOI： 10.1016/j.neuron.2005.06.014
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173