Literature DB >> 16101583

Synthesis and QSAR studies on thiazolidinones as anti-HIV agents.

Ravindra K Rawal1, V Raja Solomon, Yenamandra S Prabhakar, S B Katti, E De Clercq.   

Abstract

Selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204 microM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.

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Year:  2005        PMID： 16101583     DOI： 10.2174/1386207054546496

Source DB:  PubMed          Journal:  Comb Chem High Throughput Screen        ISSN： 1386-2073            Impact factor:   1.339


  3 in total

1.  Molecular docking studies on 4-thiazolidinones as HIV-1 RT inhibitors.

Authors:  Ravindra K Rawal; Ashutosh Kumar; Mohammad Imran Siddiqi; Setu B Katti
Journal:  J Mol Model       Date:  2006-09-13       Impact factor: 1.810

2.  Synthesis, Characterization, Antimicrobial Studies and Corrosion Inhibition Potential of 1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane: Experimental and Quantum Chemical Studies.

Authors:  Henry U Nwankwo; Collins N Ateba; Lukman O Olasunkanmi; Abolanle S Adekunle; David A Isabirye; Damian C Onwudiwe; Eno E Ebenso
Journal:  Materials (Basel)       Date:  2016-02-11       Impact factor: 3.623

3.  Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.

Authors:  Ravindra K Rawal; S B Katti; Neerja Kaushik-Basu; Payal Arora; Zhenhua Pan
Journal:  Bioorg Med Chem Lett       Date:  2008-10-08       Impact factor: 2.823
  3 in total

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