Literature DB >> 16101387

The role of Abeta peptides in Alzheimer's disease.

Anna K Tickler1, John D Wade, Frances Separovic.   

Abstract

The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Abeta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.

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Year:  2005        PMID： 16101387     DOI： 10.2174/0929866054395905

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  12 in total

1.  Endogenous overproduction of beta-amyloid induces tau hyperphosphorylation and decreases the solubility of tau in N2a cells.

Authors:  Y-P Wang; X-C Wang; Q Tian; Y Yang; Q Zhang; J-Y Zhang; Y-C Zhang; Z-F Wang; Q Wang; H Li; J-Z Wang
Journal:  J Neural Transm (Vienna)       Date:  2006-06-06       Impact factor: 3.575

2.  Effects of Abeta1-42 on the subunits of KATP expression in cultured primary rat basal forebrain neurons.

Authors:  Guozhao Ma; Qingxi Fu; Yong Zhang; Jianxin Gao; Jinjiao Jiang; Ailing Bi; Kejing Liu; Yifeng Du; Chunfu Chen; Yuanxiao Cui; Lin Lu
Journal:  Neurochem Res       Date:  2008-03-12       Impact factor: 3.996

3.  Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.

Authors:  Xiao-Chuan Wang; Yin-Chun Zhang; Nithiananda Chatterjie; Inge Grundke-Iqbal; Khalid Iqbal; Jian-Zhi Wang
Journal:  Neurochem Res       Date:  2008-01-31       Impact factor: 3.996

4.  Metal effects on the membrane interactions of amyloid-beta peptides.

Authors:  John D Gehman; Caitlin C O'Brien; Fazel Shabanpoor; John D Wade; Frances Separovic
Journal:  Eur Biophys J       Date:  2008-01-25       Impact factor: 1.733

5.  Diazoxide reverses the enhanced expression of KATP subunits in cholinergic neurons caused by exposure to Aβ₁₋₄₂.

Authors:  Guozhao Ma; Jianxin Gao; Qingxi Fu; Liangliang Jiang; Ruixia Wang; Yong Zhang; Kejing Liu
Journal:  Neurochem Res       Date:  2009-12       Impact factor: 3.996

6.  Integration of a miniature quartz crystal microbalance with a microfluidic chip for amyloid beta-Aβ42 quantitation.

Authors:  Wenyan Tao; Qingji Xie; Hairui Wang; Shanming Ke; Peng Lin; Xierong Zeng
Journal:  Sensors (Basel)       Date:  2015-10-12       Impact factor: 3.576

7.  Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology.

Authors:  Yanlin Wang; Gopal Thinakaran; Satyabrata Kar
Journal:  PLoS One       Date:  2014-05-20       Impact factor: 3.240

8.  Key network approach reveals new insight into Alzheimer's disease.

Authors:  Jan K Schluesener; Xiaomei Zhu; Hermann J Schluesener; Gao-Wei Wang; Ping Ao
Journal:  IET Syst Biol       Date:  2014-08       Impact factor: 1.615

9.  Regulation of adenosine triphosphate-sensitive potassium channels suppresses the toxic effects of amyloid-beta peptide (25-35).

Authors:  Min Kong; Maowen Ba; Hui Liang; Peng Shao; Tianxia Yu; Ying Wang
Journal:  Neural Regen Res       Date:  2013-01-05       Impact factor: 5.135

Review 10.  Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds.

Authors:  Sandeep Kumar Singh; Saurabh Srivastav; Amarish Kumar Yadav; Saripella Srikrishna; George Perry
Journal:  Oxid Med Cell Longev       Date:  2015-12-28       Impact factor: 6.543
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