OBJECTIVE: Although several studies have suggested that early menarche is associated with the development of adult overweight, few have accounted for childhood overweight before menarche. STUDY DESIGN: A 30-year follow-up of the original participants in the Newton Girls Study, a prospective study of development in a cohort of girls followed through menarche, provided data on premenarcheal relative weight and overweight (BMI >85th percentile), prospectively obtained age at menarche, self-reported adult BMI, overweight (BMI > 25), obesity (BMI > 30) and, for a subset of participants, percentage body fat by dual-energy x-ray absorptiometry. RESULTS: Of the 448 women who participated in the adult follow-up at a mean age of 42.1 years (SD: 0.76 years), 307 had childhood data with which to characterize premenarcheal and menarcheal weight status and age at menarche. After a follow-up of 30.1 years (SD: 1.4 years), reported BMI was 23.4 (4.8), 28% were overweight, and 9% were obese. In multivariate linear and logistic-regression analyses, almost all of the influence on adult weight status was a result of premenarcheal weight status (model R2 = 0.199). Inclusion of a variable to reflect menarcheal timing provided very little additional information (model R2 = 0.208). Girls who were overweight before menarche were 7.7 times more likely to be overweight as adults (95% confidence interval: 2.3, 25.8), whereas early menarche (at < or = 12 years of age) did not elevate risk (odds ratio: 1.3, 95% confidence interval: 0.66, 2.43). A similar pattern of results was observed when percentage body fat in adulthood was evaluated. CONCLUSIONS: The apparent influence of early maturation on adult female overweight is largely a result of the influence of elevated relative weight on early maturation. Interventions to prevent and treat overweight should focus on girls before they begin puberty.
OBJECTIVE: Although several studies have suggested that early menarche is associated with the development of adult overweight, few have accounted for childhood overweight before menarche. STUDY DESIGN: A 30-year follow-up of the original participants in the Newton Girls Study, a prospective study of development in a cohort of girls followed through menarche, provided data on premenarcheal relative weight and overweight (BMI >85th percentile), prospectively obtained age at menarche, self-reported adult BMI, overweight (BMI > 25), obesity (BMI > 30) and, for a subset of participants, percentage body fat by dual-energy x-ray absorptiometry. RESULTS: Of the 448 women who participated in the adult follow-up at a mean age of 42.1 years (SD: 0.76 years), 307 had childhood data with which to characterize premenarcheal and menarcheal weight status and age at menarche. After a follow-up of 30.1 years (SD: 1.4 years), reported BMI was 23.4 (4.8), 28% were overweight, and 9% were obese. In multivariate linear and logistic-regression analyses, almost all of the influence on adult weight status was a result of premenarcheal weight status (model R2 = 0.199). Inclusion of a variable to reflect menarcheal timing provided very little additional information (model R2 = 0.208). Girls who were overweight before menarche were 7.7 times more likely to be overweight as adults (95% confidence interval: 2.3, 25.8), whereas early menarche (at < or = 12 years of age) did not elevate risk (odds ratio: 1.3, 95% confidence interval: 0.66, 2.43). A similar pattern of results was observed when percentage body fat in adulthood was evaluated. CONCLUSIONS: The apparent influence of early maturation on adult female overweight is largely a result of the influence of elevated relative weight on early maturation. Interventions to prevent and treat overweight should focus on girls before they begin puberty.
Authors: Michael M Vanyukov; Ralph E Tarter; Galina P Kirillova; Levent Kirisci; Maureen D Reynolds; Mary Jeanne Kreek; Kevin P Conway; Brion S Maher; William G Iacono; Laura Bierut; Michael C Neale; Duncan B Clark; Ty A Ridenour Journal: Drug Alcohol Depend Date: 2012-01-18 Impact factor: 4.492
Authors: Ellen W Demerath; Laura L Jones; Nicola L Hawley; Shane A Norris; John M Pettifor; Dana Duren; W Cameron Chumlea; Bradford Towne; Noel Cameron Journal: J Pediatr Date: 2009-05-15 Impact factor: 4.406
Authors: J C Lo; B Maring; M Chandra; S R Daniels; A Sinaiko; M F Daley; N E Sherwood; E O Kharbanda; E D Parker; K F Adams; R J Prineas; D J Magid; P J O'Connor; L C Greenspan Journal: Pediatr Obes Date: 2013-05-15 Impact factor: 4.000
Authors: Kirsten Krahnstoever Davison; Jessica L Werder; Stewart G Trost; Birgitta L Baker; Leann L Birch Journal: Soc Sci Med Date: 2007-04-23 Impact factor: 4.634