| Literature DB >> 16099636 |
Mark H Ginsberg1, Anthony Partridge, Sanford J Shattil.
Abstract
Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified. However, a key unresolved question is how integrins propagate signals across the plasma membrane.Mesh:
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Year: 2005 PMID: 16099636 DOI: 10.1016/j.ceb.2005.08.010
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN: 0955-0674 Impact factor: 8.382