Literature DB >> 16099113

Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments.

Beatriz Lara1, Dominique Mengin-Lecreulx, Juan A Ayala, Jean van Heijenoort.   

Abstract

Blocking peptidoglycan synthesis in Escherichia coli with moenomycin or vancomycin led to the accumulation of UDP-MurNAc-pentapeptide and of its immediate upstream precursors, whereas with cephaloridine or penicillin G the pool of UDP-MurNAc-pentapeptide decreased. With MraY and FtsW deficiencies the decrease of UDP-MurNAc-pentapeptide was accompanied by an increase of the upstream nucleotide precursors and the appearance of UDP-MurNAc-tetrapeptide.

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Year:  2005        PMID： 16099113     DOI： 10.1016/j.femsle.2005.07.005

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  13 in total

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