Bruno F Casanova1, Mary D Sammel, George A Macones. 1. Department of Obstetrics and Gynecology, Pennsylvania Hospital, University of Pennsylvania, Philadelphia 19107, USA. casanovb@pahosp.com
Abstract
OBJECTIVE: The purpose of this study was to elucidate if anemia in pregnancy caused by iron deficiency could be predicted by simple measures obtained on a complete blood count (CBC) using ferritin as the gold standard. STUDY DESIGN: One hundred forty-one pregnant patients with anemia were recruited during their first prenatal visit. CBC and ferritin level were obtained and candidate-predictors identified. Receiver operator characteristic (ROC) curves, stratified analysis, and logistic regression analysis were used to develop a prediction rule with maximum specificity. RESULTS: A hemoglobin level < or = 9.7 and a red cell distribution width (RDW) > or = 15 (in gestational age <20 weeks) predicted iron deficiency with high specificity. Our final model correctly classified 79.43% of the patients (area under the ROC curve of 0.88 [95%CI 0.82-0.93], specificity of 95.74%). CONCLUSION: Iron deficiency anemia can be predicted in pregnancy using lower cost tests, which could be an incredibly useful tool in areas with limited resources and a high prevalence of the disease. This study was limited to a mostly African American population in an urban setting, and the results may not be generalized to other populations.
OBJECTIVE: The purpose of this study was to elucidate if anemia in pregnancy caused by iron deficiency could be predicted by simple measures obtained on a complete blood count (CBC) using ferritin as the gold standard. STUDY DESIGN: One hundred forty-one pregnant patients with anemia were recruited during their first prenatal visit. CBC and ferritin level were obtained and candidate-predictors identified. Receiver operator characteristic (ROC) curves, stratified analysis, and logistic regression analysis were used to develop a prediction rule with maximum specificity. RESULTS: A hemoglobin level < or = 9.7 and a red cell distribution width (RDW) > or = 15 (in gestational age <20 weeks) predicted iron deficiency with high specificity. Our final model correctly classified 79.43% of the patients (area under the ROC curve of 0.88 [95%CI 0.82-0.93], specificity of 95.74%). CONCLUSION:Iron deficiency anemia can be predicted in pregnancy using lower cost tests, which could be an incredibly useful tool in areas with limited resources and a high prevalence of the disease. This study was limited to a mostly African American population in an urban setting, and the results may not be generalized to other populations.
Authors: Kurt T Barnhart; Bruno Casanova; Mary D Sammel; Kelly Timbers; Karine Chung; J L Kulp Journal: Obstet Gynecol Date: 2008-12 Impact factor: 7.661
Authors: José Carlos Jaime-Pérez; Gisela García-Arellano; Nereida Méndez-Ramírez; Óscar González-Llano; David Gómez-Almaguer Journal: Rev Bras Hematol Hemoter Date: 2015-02-17
Authors: Ulrike Spary-Kainz; Thomas Semlitsch; Sophie Rundel; Alexander Avian; Sereina Herzog; Heidelinde Jakse; Andrea Siebenhofer Journal: Wien Klin Wochenschr Date: 2019-05-16 Impact factor: 1.704