OBJECTIVE: The authors investigated a possible cortical brain dysfunction associated with infantile autism. METHOD: They measured regional cerebral blood flow with single photon emission computed tomography (SPECT) and xenon-133 in 21 children with primary autism (according to DSM-III-R criteria). Five cortical brain areas including frontal, temporal, and sensory association cortices were examined in order to test the recent hypothesis of cerebral dysfunction in primary autism. Anatomical references for each subject were obtained with computerized tomography or magnetic resonance imaging and were used to delimit the regions of interest for SPECT analysis. RESULTS: When the results from the group with primary autism were compared with an age-matched group of nonautistic children with slight to moderate language disorders (N = 14), no cortical regional abnormalities were found. CONCLUSIONS: It appears that there is no regional cortical dysfunction in primary autism; however, in light of methodological limitations, one cannot exclude the possibility of more localized or subcortical brain dysfunctions in autism.
OBJECTIVE: The authors investigated a possible cortical brain dysfunction associated with infantile autism. METHOD: They measured regional cerebral blood flow with single photon emission computed tomography (SPECT) and xenon-133 in 21 children with primary autism (according to DSM-III-R criteria). Five cortical brain areas including frontal, temporal, and sensory association cortices were examined in order to test the recent hypothesis of cerebral dysfunction in primary autism. Anatomical references for each subject were obtained with computerized tomography or magnetic resonance imaging and were used to delimit the regions of interest for SPECT analysis. RESULTS: When the results from the group with primary autism were compared with an age-matched group of nonautistic children with slight to moderate language disorders (N = 14), no cortical regional abnormalities were found. CONCLUSIONS: It appears that there is no regional cortical dysfunction in primary autism; however, in light of methodological limitations, one cannot exclude the possibility of more localized or subcortical brain dysfunctions in autism.
Authors: Marco Pagani; Irina Manouilenko; Sharon Stone-Elander; Richard Odh; Dario Salmaso; Robert Hatherly; Fredrik Brolin; Hans Jacobsson; Stig A Larsson; Susanne Bejerot Journal: J Autism Dev Disord Date: 2012-02
Authors: E Petit; J Hérault; J Martineau; A Perrot; C Barthélémy; L Hameury; D Sauvage; G Lelord; J P Müh Journal: J Med Genet Date: 1995-04 Impact factor: 6.318
Authors: Daniel A Rossignol; James J Bradstreet; Kyle Van Dyke; Cindy Schneider; Stuart H Freedenfeld; Nancy O'Hara; Stephanie Cave; Julie A Buckley; Elizabeth A Mumper; Richard E Frye Journal: Med Gas Res Date: 2012-06-15