| Literature DB >> 16098690 |
Olivier Dussurget1, Emilie Dumas, Cristel Archambaud, Ingrid Chafsey, Christophe Chambon, Michel Hébraud, Pascale Cossart.
Abstract
In this study, the role of Listeria monocytogenes ferritin was investigated. The fri gene encoding the ferritin was deleted and the phenotype of the mutant was analyzed demonstrating that ferritin is necessary for optimal growth in minimal medium in both presence and absence of iron, as well as after cold- and heat-shock. We also showed that ferritin provides protection against reactive oxygen species and is essential for full virulence of L. monocytogenes. A comparative proteomic analysis revealed an effect of the fri deletion on the levels of listeriolysin O and several stress proteins. Together, our study demonstrates that fri has multiple roles that contribute to Listeria virulence.Entities:
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Year: 2005 PMID： 16098690 DOI： 10.1016/j.femsle.2005.07.015
Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742