BACKGROUND: This phase II cooperative group study of patients with unresectable stage III non-small-cell lung cancer was designed to treat patients with induction chemotherapy with paclitaxel and carboplatin (PC) followed by concurrent chemotherapy with the same chemotherapy plus thoracic irradiation to 66 Gy. PATIENTS AND METHODS: All enrolled patients were scheduled to receive 2 cycles of induction PC at conventional doses. All nonprogressing patients were subsequently treated with concurrent chemoradiation, including 7 weekly doses of PC and once-daily thoracic irradiation. The eligibility criteria allowed treatment of an expanded population of patients, unrestricted by previous weight loss. RESULTS: Despite the fact that 22% of patients had experienced > 5% weight loss in the preceding 6 months, 23 of the 40 eligible patients (58%) responded to the overall regimen. A 3-year failure-free survival rate of 15% and a 3-year overall survival rate of 27% were achieved. The 3-year overall survival rate is consistent with landmark cooperative group results for the combined modality treatment of a more highly selected patient population. CONCLUSION: The feasibility of this therapeutic approach in a cooperative group setting and inclusive of patients who were representative of the general population of stage III lung cancer patients was established.
BACKGROUND: This phase II cooperative group study of patients with unresectable stage III non-small-cell lung cancer was designed to treat patients with induction chemotherapy with paclitaxel and carboplatin (PC) followed by concurrent chemotherapy with the same chemotherapy plus thoracic irradiation to 66 Gy. PATIENTS AND METHODS: All enrolled patients were scheduled to receive 2 cycles of induction PC at conventional doses. All nonprogressing patients were subsequently treated with concurrent chemoradiation, including 7 weekly doses of PC and once-daily thoracic irradiation. The eligibility criteria allowed treatment of an expanded population of patients, unrestricted by previous weight loss. RESULTS: Despite the fact that 22% of patients had experienced > 5% weight loss in the preceding 6 months, 23 of the 40 eligible patients (58%) responded to the overall regimen. A 3-year failure-free survival rate of 15% and a 3-year overall survival rate of 27% were achieved. The 3-year overall survival rate is consistent with landmark cooperative group results for the combined modality treatment of a more highly selected patient population. CONCLUSION: The feasibility of this therapeutic approach in a cooperative group setting and inclusive of patients who were representative of the general population of stage III lung cancerpatients was established.
Authors: Xiaofei Wang; Lin Gu; Ying Zhang; Daniel J Sargent; William Richards; Apar Kishor Ganti; Jeffery Crawford; Harvey Jay Cohen; Thomas Stinchcombe; Everett Vokes; Herbert Pang Journal: Lung Cancer Date: 2015-08-18 Impact factor: 5.705
Authors: Thomas E Stinchcombe; Ying Zhang; Everett E Vokes; Joan H Schiller; Jeffrey D Bradley; Karen Kelly; Walter J Curran; Steven E Schild; Benjamin Movsas; Gerald Clamon; Ramaswamy Govindan; George R Blumenschein; Mark A Socinski; Neal E Ready; Wallace L Akerley; Harvey J Cohen; Herbert H Pang; Xiaofei Wang Journal: J Clin Oncol Date: 2017-05-11 Impact factor: 44.544
Authors: Rafael Santana-Davila; Kiran Devisetty; Aniko Szabo; Rodney Sparapani; Carlos Arce-Lara; Elizabeth M Gore; Amy Moran; Christina D Williams; Michael J Kelley; Jeffrey Whittle Journal: J Clin Oncol Date: 2014-11-24 Impact factor: 44.544
Authors: Thomas E Stinchcombe; Lydia Hodgson; James E Herndon; Michael J Kelley; M Giulia Cicchetti; Nithya Ramnath; Harvey B Niell; James N Atkins; Wallace Akerley; Mark R Green; Everett E Vokes Journal: J Thorac Oncol Date: 2009-09 Impact factor: 15.609