Literature DB >> 160972

Influence of SOS repair on the specificity of radiation mutagenesis in bacteriophage phiX174.

J F Bleichrodt, W S Roos-Verheij.   

Abstract

The ochre mutant oc9 of bacteriophage phiX174 was irradiated with gamma-rays and the revertants were assayed on unirradiated and UV-irradiated host bacteria carrying an amber suppressor. The yield of revertants (amber + wild type) was higher on UV-irradiated than on unirradiated bacteria, showing that gamma-irradiated phiX174 was subjected to W-mutagenesis. For oc9 gamma-irradiated in the presence of oxygen the fraction of amber mutants among the revertants was lower when mutants were scored on UV-irradiated bacteria than when assayed on unirradiated indicator cells. The same fraction of ambers was obtained when mutants were assayed on unirradiated and UV-irradiated samples of a recA indicator strain. UV-irradiated phiX174 showed a similar phenomenon. These results suggest that the specificity with regard to insertion of bases opposite radiation damage in phiX174 DNA is different for host cells in which SOS repair has been induced and cells in which SOS repair is not operative.

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Year:  1979        PMID： 160972     DOI： 10.1007/bf00273209

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  17 in total

1.  Induction of Mutations in a Bacterial Virus.

Authors:  J J Weigle
Journal:  Proc Natl Acad Sci U S A       Date:  1953-07       Impact factor: 11.205

2.  Enzymatic photoreactivation of Escherichia coli after lonizing irradiation: chemical evidence for the production of pyrimidine dimers.

Authors:  T V Wang; K C Smith
Journal:  Radiat Res       Date:  1978-12       Impact factor: 2.841

3.  Induction of mutations in bacteriophage T7 by gamma-rays: independence of host-repair mechanisms.

Authors:  J F Bleichrodt; A L Roos; W S Roos-Verheij
Journal:  Mutat Res       Date:  1977-06       Impact factor: 2.433

4.  Molecular mechanisms of induced mutagenesis. Replication in vivo of bacteriophage phiX174 single-stranded, ultraviolet light-irradiated DNA in intact and irradiated host cells.

Authors:  P Caillet-Fauquet; M Defais; M Radman
Journal:  J Mol Biol       Date:  1977-11-25       Impact factor: 5.469

5.  Genetic recombination in bacteriophage phi chi 174.

Authors:  R M Benbow; A J Zuccarelli; G C Davis; R L Sinsheimer
Journal:  J Virol       Date:  1974-04       Impact factor: 5.103

6.  Influence of oxygen on the induction of mutations in bacteriophage phi chi 174 by ionizing radiation.

Authors:  J F Bleichrodt; W S Verheij
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1974-05

7.  Studies on radiation-sensitive mutants of E. coli. 3. Participation of the rec system in induction of mutation by ultraviolet irradiation.

Authors:  A Miura; J I Tomizawa
Journal:  Mol Gen Genet       Date:  1968

8.  Ultraviolet reactivation and ultraviolet mutagenesis of lambda in different genetic systems.

Authors:  M Defais; P Fauquet; M Radman; M Errera
Journal:  Virology       Date:  1971-02       Impact factor: 3.616

Review 9.  Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

10.  The nucleotide sequence of bacteriophage phiX174.

Authors:  F Sanger; A R Coulson; T Friedmann; G M Air; B G Barrell; N L Brown; J C Fiddes; C A Hutchison; P M Slocombe; M Smith
Journal:  J Mol Biol       Date:  1978-10-25       Impact factor: 5.469
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  1 in total

1.  DNA repair in B. subtilis: an inducible dimer specific W-reactivation system.

Authors:  P I Fields; R E Yasbin
Journal:  Mol Gen Genet       Date:  1983
  1 in total

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