AIM: Alpha-lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats. METHODS: ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 microg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase, amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis. RESULTS: ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However, the secretion of IL-1beta, IL-6, and TNF-alpha were comparable in CCK octapeptide-induced acute pancreatitis. CONCLUSION: ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.
AIM: Alpha-lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats. METHODS:ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 microg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase, amylase of serum. Repeated CCKoctapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis. RESULTS:ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCKoctapeptide-induced acute pancreatitis. However, the secretion of IL-1beta, IL-6, and TNF-alpha were comparable in CCKoctapeptide-induced acute pancreatitis. CONCLUSION:ALA may have a protective effect against CCKoctapeptide-induced acute pancreatitis.
Authors: B Rau; B Poch; F Gansauge; A Bauer; A K Nüssler; T Nevalainen; M H Schoenberg; H G Beger Journal: Ann Surg Date: 2000-03 Impact factor: 12.969
Authors: Salvatore Cuzzocrea; Emanuela Mazzon; Laura Dugo; Tommaso Centorrino; Antonio Ciccolo; Michelle C McDonald; Agelina de Sarro; Achille P Caputi; Christoph Thiemermann Journal: Cytokine Date: 2002-06-07 Impact factor: 3.861