AIM: To investigate whether S100A4 played an important role in the development or progression of colorectal cancer. METHODS: A total of 124 colorectal adenocarcinoma tissue specimens were analyzed by immunohistochemistry for the expression of S100A4 protein and subsequently investigated for the gene mutations in the coding region of S100A4 gene. The specimens were collected over a 3-year period in the laboratories at our large teaching hospital in Seoul, Republic of Korea. RESULTS: Normal colonic epithelium either failed to express or showed focal weak expression of S100A4. Moderate to strong cytoplasmic expression of S100A4 was seen in 69 (55.6%) of the 124 colorectal carcinoma tissue specimens. S100A4 expression was detected in 43 (69.4%) of 62 specimens with lymph node metastasis. Statistically, overexpression of S100A4 was significantly associated with Dukes' stage and lymph node metastasis. Nuclear staining was also observed in 24 (19.4%) of 124 samples and closely associated with Dukes' stage. However, there was no significant correlation between overexpression of S100A4 and other investigated clinico-pathologic parameters, including tumor localization, tumor size, and survival period. In mutational analysis, no gene mutation was found in the analyzed genomic area of colorectal cancer. CONCLUSION: Overexpression of S100A4 may be closely related with the aggressiveness of colorectal carcinoma.
AIM: To investigate whether S100A4 played an important role in the development or progression of colorectal cancer. METHODS: A total of 124 colorectal adenocarcinoma tissue specimens were analyzed by immunohistochemistry for the expression of S100A4 protein and subsequently investigated for the gene mutations in the coding region of S100A4 gene. The specimens were collected over a 3-year period in the laboratories at our large teaching hospital in Seoul, Republic of Korea. RESULTS: Normal colonic epithelium either failed to express or showed focal weak expression of S100A4. Moderate to strong cytoplasmic expression of S100A4 was seen in 69 (55.6%) of the 124 colorectal carcinoma tissue specimens. S100A4 expression was detected in 43 (69.4%) of 62 specimens with lymph node metastasis. Statistically, overexpression of S100A4 was significantly associated with Dukes' stage and lymph node metastasis. Nuclear staining was also observed in 24 (19.4%) of 124 samples and closely associated with Dukes' stage. However, there was no significant correlation between overexpression of S100A4 and other investigated clinico-pathologic parameters, including tumor localization, tumor size, and survival period. In mutational analysis, no gene mutation was found in the analyzed genomic area of colorectal cancer. CONCLUSION: Overexpression of S100A4 may be closely related with the aggressiveness of colorectal carcinoma.
Authors: K Bjørnland; J O Winberg; O T Odegaard; E Hovig; T Loennechen; A O Aasen; O Fodstad; G M Maelandsmo Journal: Cancer Res Date: 1999-09-15 Impact factor: 12.701
Authors: D J Slamon; W Godolphin; L A Jones; J A Holt; S G Wong; D E Keith; W J Levin; S G Stuart; J Udove; A Ullrich Journal: Science Date: 1989-05-12 Impact factor: 47.728
Authors: Yong Gu Cho; Suk Woo Nam; Tae Yon Kim; Young Sil Kim; Chang Jae Kim; Jik Young Park; Jong Heun Lee; Hong Sug Kim; Jong Woo Lee; Cho Hyun Park; Young Hwa Song; Sug Hyung Lee; Nam Jin Yoo; Jung Young Lee; Won Sang Park Journal: APMIS Date: 2003-05 Impact factor: 3.205
Authors: Christo D Venkov; Andrew J Link; Jennifer L Jennings; David Plieth; Tsutomu Inoue; Kojiro Nagai; Carol Xu; Yoana N Dimitrova; Frank J Rauscher; Eric G Neilson Journal: J Clin Invest Date: 2007-02 Impact factor: 14.808
Authors: Ulrike Stein; Susen Burock; Pia Herrmann; Ina Wendler; Markus Niederstrasser; Klaus-Dieter Wernecke; Peter M Schlag Journal: J Mol Diagn Date: 2011-03 Impact factor: 5.568
Authors: Ulrike Stein; Franziska Arlt; Janice Smith; Ulrike Sack; Pia Herrmann; Wolfgang Walther; Margit Lemm; Iduna Fichtner; Robert H Shoemaker; Peter M Schlag Journal: Neoplasia Date: 2011-02 Impact factor: 5.715
Authors: P S S Kho; L Jankova; C L-S Fung; C Chan; C Clarke; B P C Lin; G Robertson; M Molloy; P H Chapuis; E L Bokey; O F Dent; S Clarke Journal: Int J Colorectal Dis Date: 2012-05-09 Impact factor: 2.571