| Literature DB >> 16096806 |
Karisa Karla Manhani1, Helen Andrade Arcuri, Nelson José Freitas da Silveira, Hugo Brandão Uchôa, Walter Filgueira de Azevedo, Fernanda Canduri.
Abstract
Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.Entities:
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Year: 2005 PMID： 16096806 DOI： 10.1007/s00894-005-0002-1
Source DB: PubMed Journal: J Mol Model ISSN： 0948-5023 Impact factor: 1.810