| Literature DB >> 16096051 |
Abstract
The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex. They show that the nicastrin extracellular domain is essential for recognition of substrate by the gamma-secretase.Entities:
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Year: 2005 PMID： 16096051 DOI： 10.1016/j.cell.2005.07.021
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582