Literature DB >> 16095971

Epitope spreading within lupus-associated ribonucleoprotein antigens.

Umesh S Deshmukh1, Harini Bagavant, Janet Lewis, Felicia Gaskin, Shu Man Fu.   

Abstract

Autoantibodies reactive with several cellular antigens are present in the sera of patients with systemic lupus erythematosus. Polypeptides within the Ro-RNP complex and the snRNP complex are often targeted by these autoantibodies. One of the mechanisms responsible for their evolution is that of epitope spreading. Experimental animal model systems provide evidence for this. This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis.

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Year:  2005        PMID： 16095971     DOI： 10.1016/j.clim.2005.07.002

Source DB:  PubMed          Journal:  Clin Immunol        ISSN： 1521-6616            Impact factor:   3.969


  18 in total

Review 1.  Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR.

Authors:  Shu Man Fu; Umesh S Deshmukh; Felicia Gaskin
Journal:  J Autoimmun       Date:  2011-06-01       Impact factor: 7.094

Review 2.  Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach.

Authors:  Christopher M Tipton; Jennifer R Hom; Christopher F Fucile; Alexander F Rosenberg; Inaki Sanz
Journal:  Immunol Rev       Date:  2018-07       Impact factor: 12.988

Review 3.  Regulatory T cells in the treatment of disease.

Authors:  Amir Sharabi; Maria G Tsokos; Ying Ding; Thomas R Malek; David Klatzmann; George C Tsokos
Journal:  Nat Rev Drug Discov       Date:  2018-10-12       Impact factor: 84.694

Review 4.  The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases.

Authors:  Nicole H Kattah; Michael G Kattah; Paul J Utz
Journal:  Immunol Rev       Date:  2010-01       Impact factor: 12.988

5.  Innate and humoral recognition of the products of cell death: differential antigenicity and immunogenicity in lupus.

Authors:  P Arora; M Malik; R Sachdeva; L Saxena; J Das; V G Ramachandran; R Pal
Journal:  Clin Exp Immunol       Date:  2016-12-05       Impact factor: 4.330

Review 6.  Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice.

Authors:  Silvia Bolland; Adolfo Garcia-Sastre
Journal:  J Exp Med       Date:  2009-07-27       Impact factor: 14.307

7.  Association of epitope spreading of antiglomerular basement membrane antibodies and kidney injury.

Authors:  Jun-liang Chen; Shui-yi Hu; Xiao-yu Jia; Juan Zhao; Rui Yang; Zhao Cui; Ming-hui Zhao
Journal:  Clin J Am Soc Nephrol       Date:  2012-10-18       Impact factor: 8.237

8.  Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis.

Authors:  Tsutomu Mori; Hiromasa Ohira; Masahito Kuroda; Masaki Kato; Yoshiki Yamaguchi; Hideo Kochi
Journal:  Int J Hepatol       Date:  2012-06-20

9.  Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling.

Authors:  Constantin Fesel; Marta Barreto; Ricardo C Ferreira; Nuno Costa; Lara L Venda; Clara Pereira; Claudia Carvalho; Maria Francisca Morães-Fontes; Carlos M Ferreira; Carlos Vasconcelos; João F Viana; Eugenia Santos; Berta Martins; Jocelyne Demengeot; Astrid M Vicente
Journal:  PLoS One       Date:  2012-03-29       Impact factor: 3.240

10.  Germinal center reutilization by newly activated B cells.

Authors:  Tanja A Schwickert; Boris Alabyev; Tim Manser; Michel C Nussenzweig
Journal:  J Exp Med       Date:  2009-11-23       Impact factor: 14.307
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