Literature DB >> 16095885

LRP 1 B functions as a receptor for Pseudomonas exotoxin.

Diana V Pastrana1, Alison J Hanson, Jane Knisely, Guojun Bu, David J Fitzgerald.   

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor.

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Year:  2005        PMID： 16095885     DOI： 10.1016/j.bbadis.2005.06.007

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis.

Authors:  Alban Gaultier; Xiaohua Wu; Natacha Le Moan; Shinako Takimoto; Gatambwa Mukandala; Katerina Akassoglou; W Marie Campana; Steven L Gonias
Journal:  J Cell Sci       Date:  2009-03-19       Impact factor: 5.285

2.  Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

Authors:  Martin F Dietrich; Louise van der Weyden; Haydn M Prosser; Allan Bradley; Joachim Herz; David J Adams
Journal:  PLoS One       Date:  2010-04-07       Impact factor: 3.240

3.  A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.

Authors:  John E Weldon; Laiman Xiang; Oleg Chertov; Inger Margulies; Robert J Kreitman; David J FitzGerald; Ira Pastan
Journal:  Blood       Date:  2008-11-06       Impact factor: 25.476

4.  LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE-carrying lipoproteins.

Authors:  J Haas; A G Beer; P Widschwendter; J Oberdanner; K Salzmann; B Sarg; H Lindner; J Herz; J R Patsch; P Marschang
Journal:  Atherosclerosis       Date:  2011-02-24       Impact factor: 5.162

5.  Bacterial Toxin Fusion Proteins Elicit Mucosal Immunity against a Foot-and-Mouth Disease Virus Antigen When Administered Intranasally to Guinea Pigs.

Authors:  Sreerupa Challa; Steven M Szczepanek; Debra Rood; Roger W Barrette; Lawrence K Silbart
Journal:  Adv Virol       Date:  2011-09-22

Review 6.  Toxin-based targeted therapy for malignant brain tumors.

Authors:  Vidyalakshmi Chandramohan; John H Sampson; Ira Pastan; Darell D Bigner
Journal:  Clin Dev Immunol       Date:  2012-02-09

Review 7.  A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.

Authors:  John E Weldon; Ira Pastan
Journal:  FEBS J       Date:  2011-06-02       Impact factor: 5.622

8.  GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

Authors:  Fikadu G Tafesse; Carla P Guimaraes; Takeshi Maruyama; Jan E Carette; Stephen Lory; Thijn R Brummelkamp; Hidde L Ploegh
Journal:  J Biol Chem       Date:  2014-07-16       Impact factor: 5.486

9.  Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor.

Authors:  Dennis Schöttelndreier; Anna Langejürgen; Robert Lindner; Harald Genth
Journal:  Front Cell Infect Microbiol       Date:  2020-10-19       Impact factor: 5.293

10.  Targeting c-Myc with a novel Peptide Nuclear Delivery Device.

Authors:  Trinda Anne Ting; Alexandre Chaumet; Frederic Andre Bard
Journal:  Sci Rep       Date:  2020-10-20       Impact factor: 4.379
  10 in total

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