Reversible focal splenial lesion of the corpus callosum on MR images in a patient with malnutrition.

T2-weighted MR (magnetic resonance) images of a 19-year-old woman undergoing concurrent chemoradiotherapy for a nasopharyngeal carcinoma revealed a lesion marked by focal hyper signal intensity in the splenium of the corpus callosum. The lesion was not visible two weeks later. She suffered from malnutrition caused by appetite loss during chemotherapy. We concluded that the lesion revealed by the abnormal signal intensity in the splenium had been caused by malnutrition.