Literature DB >> 16092880

The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst.

Niloufar Hadei1, Eric Assen B Kantchev, Christopher J O'Brien, Michael G Organ.   

Abstract

The development of an NHC-based system capable of cross-coupling sp(3)-sp(3) centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. [reaction: see text]

Entities:  

Year:  2005        PMID： 16092880     DOI： 10.1021/ol0514909

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  13 in total

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3.  Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling.

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Review 4.  Advances in transition metal (Pd, Ni, Fe)-catalyzed cross-coupling reactions using alkyl-organometallics as reaction partners.

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10.  Total synthesis of the anti-inflammatory and pro-resolving lipid mediator MaR1n-3 DPA utilizing an sp(3) -sp(3) Negishi cross-coupling reaction.

Authors:  Jørn Eivind Tungen; Marius Aursnes; Jesmond Dalli; Hildur Arnardottir; Charles Nicholas Serhan; Trond Vidar Hansen
Journal:  Chemistry       Date:  2014-09-15       Impact factor: 5.236
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