Literature DB >> 1609278

Triple helix-specific ligands.

J L Mergny1, G Duval-Valentin, C H Nguyen, L Perrouault, B Faucon, M Rougée, T Montenay-Garestier, E Bisagni, C Hélène.   

Abstract

A triple helix is formed upon binding of an oligodeoxynucleotide to the major groove of duplex DNA. A benzo[e]pyridoindole derivative (BePI) strongly stabilized this structure and showed preferential binding to a triplex rather than to a duplex. Energy transfer experiments suggest that BePI intercalates within the triple helix. Sequence-specific inhibition of transcription initiation of a specific gene by Escherichia coli RNA polymerase by a triplex-forming oligodeoxynucleotide is strongly enhanced when the triplex is stabilized by BePI. Upon irradiation with ultraviolet light, BePI induces covalent modifications of the target within the triple helix structure.

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Year:  1992        PMID： 1609278     DOI： 10.1126/science.256.5064.1681

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  52 in total

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2.  Controlling nucleic acid secondary structure by intercalation: effects of DNA strand length on coralyne-driven duplex disproportionation.

Authors:  Swapan S Jain; Matjaz Polak; Nicholas V Hud
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3.  DNA sequence specificity of a naphthylquinoline triple helix-binding ligand.

Authors:  S A Cassidy; L Strekowski; K R Fox
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

4.  A gold nanoparticle based approach for screening triplex DNA binders.

Authors:  Min Su Han; Abigail K R Lytton-Jean; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2006-04-19       Impact factor: 15.419

5.  Use of a pyrimidine nucleoside that functions as a bidentate hydrogen bond donor for the recognition of isolated or contiguous G-C base pairs by oligonucleotide-directed triplex formation.

Authors:  G Xiang; R Bogacki; L W McLaughlin
Journal:  Nucleic Acids Res       Date:  1996-05-15       Impact factor: 16.971

6.  Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands.

Authors:  M D Keppler; S Neidle; K R Fox
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

7.  Microarray detection of duplex and triplex DNA binders with DNA-modified gold nanoparticles.

Authors:  Abigail K R Lytton-Jean; Min Su Han; Chad A Mirkin
Journal:  Anal Chem       Date:  2007-07-06       Impact factor: 6.986

Review 8.  Antiviral therapy for human immunodeficiency virus infections.

Authors:  E De Clercq
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9.  Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents.

Authors:  Sebastian Rykowski; Dorota Gurda-Woźna; Marta Orlicka-Płocka; Agnieszka Fedoruk-Wyszomirska; Małgorzata Giel-Pietraszuk; Eliza Wyszko; Aleksandra Kowalczyk; Paweł Stączek; Andrzej Bak; Agnieszka Kiliszek; Wojciech Rypniewski; Agnieszka B Olejniczak
Journal:  Int J Mol Sci       Date:  2021-03-09       Impact factor: 5.923

10.  Formation of a parallel-stranded DNA homoduplex by d(GGA) repeat oligonucleotides.

Authors:  T Suda; Y Mishima; H Asakura; R Kominami
Journal:  Nucleic Acids Res       Date:  1995-09-25       Impact factor: 16.971
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