Aditya K Gupta1, Melody Chow. 1. Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Science Center, Sunnybrook site and the University of Toronto, Toronto, Canada. agupta@execulink.com
Abstract
BACKGROUND: Topical steroids have been a popular choice for treating various cutaneous disorders; however, the potential for significant local and systemic adverse events, like skin atrophy and hypothalamic-pituitary-adrenal (HPA) axis suppression, has limited their use. OBJECTIVE: This article reviews the topical steroid prednicarbate through its mechanism of action, clinical efficacy, and adverse events profile. METHODS: Published literature containing the word "prednicarbate" was examined and summarized. RESULTS: Prednicarbate is a nonhalogenated, double-ester derivative of prednisolone that has been used in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as atopic dermatitis. It has a favorable benefit-risk ratio, low skin atrophy potential, and high anti-inflammatory action. CONCLUSION: These characteristics make prednicarbate an ideal alternative agent for children, elderly patients, and those who require long-term intermittent treatment.
BACKGROUND: Topical steroids have been a popular choice for treating various cutaneous disorders; however, the potential for significant local and systemic adverse events, like skin atrophy and hypothalamic-pituitary-adrenal (HPA) axis suppression, has limited their use. OBJECTIVE: This article reviews the topical steroidprednicarbate through its mechanism of action, clinical efficacy, and adverse events profile. METHODS: Published literature containing the word "prednicarbate" was examined and summarized. RESULTS:Prednicarbate is a nonhalogenated, double-ester derivative of prednisolone that has been used in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as atopic dermatitis. It has a favorable benefit-risk ratio, low skin atrophy potential, and high anti-inflammatory action. CONCLUSION: These characteristics make prednicarbate an ideal alternative agent for children, elderly patients, and those who require long-term intermittent treatment.
Authors: Joo Wan Kim; Sae-Kwang Ku; Min Ho Han; Ki Young Kim; Sung Goo Kim; Gi-Young Kim; Hye Jin Hwang; Byung Woo Kim; Cheol Min Kim; Yung Hyun Choi Journal: Int J Mol Med Date: 2015-05-04 Impact factor: 4.101