AIM: To study antioxidative defense in patients with acute coronary syndrome (ACS) and concomitant type 2 diabetes and its modification bylisinopril. MATERIAL AND METHODS: Activity of glutathione reductase and myeloperoxidase in neutrophils, catalase and superoxide dismutase in blood was measured in 94 patients with ACS (including 35 with diabetes) and the patients were followed up for 1 year. RESULTS:Number of coronary events during observation was significantly higher in patients with diabetes. At baseline these patients had significantly lower catalase activity which was associated with elevated blood glucose, circulating immune complexes, creatinine, and proteinuria. Baseline catalase activity was the lowest in diabetic patients with events (reinfarction or death) during follow-up. The latter patients had highest levels of blood creatinine and proteinuria, and most pronounced left ventricular systolic dysfunction. The use of lisinopril during initial hospitalization was associated with elevation of catalase activity, lowering of creatinine and elimination of proteinuria.
RCT Entities:
AIM: To study antioxidative defense in patients with acute coronary syndrome (ACS) and concomitant type 2 diabetes and its modification by lisinopril. MATERIAL AND METHODS: Activity of glutathione reductase and myeloperoxidase in neutrophils, catalase and superoxide dismutase in blood was measured in 94 patients with ACS (including 35 with diabetes) and the patients were followed up for 1 year. RESULTS: Number of coronary events during observation was significantly higher in patients with diabetes. At baseline these patients had significantly lower catalase activity which was associated with elevated blood glucose, circulating immune complexes, creatinine, and proteinuria. Baseline catalase activity was the lowest in diabeticpatients with events (reinfarction or death) during follow-up. The latter patients had highest levels of blood creatinine and proteinuria, and most pronounced left ventricular systolic dysfunction. The use of lisinopril during initial hospitalization was associated with elevation of catalase activity, lowering of creatinine and elimination of proteinuria.