| Literature DB >> 16091286 |
Christofer V Samuelsson1, Stefan Lienenklaus, Peter P Müller, Rainer Zawatzky, Hansjörg Hauser, Siegfried Weiss.
Abstract
Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-beta plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-alpha4 can be induced independently of IFN-beta. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-beta.Entities:
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Year: 2005 PMID： 16091286 DOI： 10.1016/j.bbrc.2005.07.124
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575