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Literature DB >> 16091239

Adherence to antiretroviral therapy: an update of current concepts.

Gregory M Lucas¹, Albert W Wu, Laura W Cheever.

Abstract

The remarkable effectiveness of combination antiretroviral therapy (CART) in the treatment of HIV infection has placed a high premium on long-term adherence to therapy. Adherence levels to CART among HIV-infected individuals are similar to adherence levels with chronic medical conditions, such as diabetes and hypertension. However, unlike chronic medical conditions, medication adherence that is insufficient to maintain suppression of HIV replication will lead to drug resistance. Combination antiretroviral therapy regimen complexity and side-effect burden are clearly linked to adherence and are likely to be the factors most amenable to intervention. Adherence interventions that are multifaceted, flexible, and protracted are the most likely to be successful. Owing to the great benefits of CART even the small to modest gains in adherence that are achievable with adherence programs may prove to be cost effective.

Entities: Disease

Mesh：

Substances：
Anti-Retroviral Agents

Year: 2004 PMID： 16091239 DOI： 10.1007/s11904-004-0027-6

Source DB: PubMed Journal: Curr HIV/AIDS Rep ISSN： 1548-3568 Impact factor: 5.071

77 in total

1. Gastrostomy tube insertion for improvement of adherence to highly active antiretroviral therapy in pediatric patients with human immunodeficiency virus.

Authors: D Shingadia; R M Viani; R Yogev; H Binns; W M Dankner; S A Spector; E G Chadwick
Journal: Pediatrics Date: 2000-06 Impact factor: 7.124

2. Computer-assisted self-interviewing (CASI) to improve provider assessment of adherence in routine clinical practice.

Authors: David R Bangsberg; Amy Bronstone; Margaret A Chesney; Federick M Hecht
Journal: J Acquir Immune Defic Syndr Date: 2002-12-15 Impact factor: 3.731

3. Metered-dose inhaler adherence in a clinical trial.

Authors: C S Rand; R A Wise; M Nides; M S Simmons; E R Bleecker; J W Kusek; V C Li; D P Tashkin
Journal: Am Rev Respir Dis Date: 1992-12

4. Disease progression, adherence, and response to protease inhibitor therapy for HIV infection in an Urban Veterans Affairs Medical Center.

Authors: K Maher; N Klimas; M A Fletcher; V Cohen; C M Maggio; J Triplett; R Valenzuela; G Dickinson
Journal: J Acquir Immune Defic Syndr Date: 1999-12-01 Impact factor: 3.731

5. Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. Trilège (Agence Nationale de Recherches sur le SIDA 072) Study Team).

Authors: D Descamps; P Flandre; V Calvez; G Peytavin; V Meiffredy; G Collin; C Delaugerre; S Robert-Delmas; B Bazin; J P Aboulker; G Pialoux; F Raffi; F Brun-Vézinet
Journal: JAMA Date: 2000-01-12 Impact factor: 56.272

6. Adolescent sexual behavior, drug use, and violence: increased reporting with computer survey technology.

Authors: C F Turner; L Ku; S M Rogers; L D Lindberg; J H Pleck; F L Sonenstein
Journal: Science Date: 1998-05-08 Impact factor: 47.728

7. Problem drinking and medication adherence among persons with HIV infection.

Authors: R L Cook; S M Sereika; S C Hunt; W C Woodward; J A Erlen; J Conigliaro
Journal: J Gen Intern Med Date: 2001-02 Impact factor: 5.128

8. Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy.

Authors: Louis Bernard; Albert Vuagnat; Gilles Peytavin; Marie-Charlotte Hallouin; Damien Bouhour; Thu Huyen Nguyen; Jean Louis Vildé; François Bricaire; Gilles Raguin; Pierre de Truchis; David Ghez; Michel Duong; Christian Perronne
Journal: Ann Intern Med Date: 2002-10-15 Impact factor: 25.391

Adherence to antiretroviral therapy: an update of current concepts.

1. Gastrostomy tube insertion for improvement of adherence to highly active antiretroviral therapy in pediatric patients with human immunodeficiency virus.

2. Computer-assisted self-interviewing (CASI) to improve provider assessment of adherence in routine clinical practice.

3. Metered-dose inhaler adherence in a clinical trial.

4. Disease progression, adherence, and response to protease inhibitor therapy for HIV infection in an Urban Veterans Affairs Medical Center.

5. Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. Trilège (Agence Nationale de Recherches sur le SIDA 072) Study Team).

6. Adolescent sexual behavior, drug use, and violence: increased reporting with computer survey technology.

7. Problem drinking and medication adherence among persons with HIV infection.

8. Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy.

9. Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study.

10. Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection.

Review 1. Motivational interviewing for improving adherence to antiretroviral medications.

2. A cost analysis of an Internet-based medication adherence intervention for people living with HIV.