[The use of bead cellulose for controlled drug liberation. 4. Binding of bead cellulose and bead cellulose-derivatives with prazosin hydrochloride and its liberation].

Pure bead cellulose and the ionic derivatives carboxymethyl and dihydrogen phosphate bead cellulose were coupled with prazosin hydrochloride. The degree of substitution achieved during loading mostly depends on the number of functional groups, what was verified by titrimetric determination of the ion exchange capacity. Because of predominant ionic binding of the protonated prazosin cation to the anionic groups of several types of bead cellulose in electrolytes containing liquids as well as in water a large amount of bonded drug is liberated considerable fast. Retardation of the liberation in comparison to the commercial product Adversuten is verified but not applicable to therapeutic use in the case of prazosin.