Literature DB >> 1608892

Microbial production of a crisnatol metabolite.

C D Hufford1, S H el-Sharkawy, T M Jurgens, J R Mikell.   

Abstract

Microbial metabolism studies of crisnatol (1), a new DNA intercalator, has resulted in the isolation and characterization of a major metabolite identified as the C-1 hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-1 hydroxylated metabolite were also made.

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Year:  1992        PMID: 1608892     DOI: 10.1023/a:1015893808830

Source DB:  PubMed          Journal:  Pharm Res        ISSN: 0724-8741            Impact factor:   4.200


  5 in total

1.  Structure elucidation and thermospray high-performance liquid chromatography/mass spectroscopy (HPLC/MS) of the microbial and mammalian metabolites of the antimalarial arteether.

Authors:  C D Hufford; I S Lee; H N ElSohly; H T Chi; J K Baker
Journal:  Pharm Res       Date:  1990-09       Impact factor: 4.200

Review 2.  Use of microorganisms for the study of drug metabolism: an update.

Authors:  A M Clark; C D Hufford
Journal:  Med Res Rev       Date:  1991-09       Impact factor: 12.944

3.  Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.

Authors:  D K Patel; J L Woolley; J P Shcokcor; R L Johnson; L C Taylor; C W Sigel
Journal:  Drug Metab Dispos       Date:  1991 Mar-Apr       Impact factor: 3.922

4.  Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites.

Authors:  D K Patel; J P Shockcor; S Y Chang; C W Sigel; B E Huber
Journal:  Biochem Pharmacol       Date:  1991-07-05       Impact factor: 5.858

Review 5.  The use of microorganisms for the study of drug metabolism.

Authors:  A M Clark; J D McChesney; C D Hufford
Journal:  Med Res Rev       Date:  1985 Apr-Jun       Impact factor: 12.944

  5 in total

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