| Literature DB >> 16088108 |
Marc Fatar1, Mark Stroick, Martin Griebe, Michael Hennerici.
Abstract
Matrix metalloproteinases are important factors for tissue remodelling and are activated during several physiological and pathological conditions, including cerebrovascular diseases. We give an overview of the structure, production and physiological effects of these widely distributed proteases and describe the genetic background and regulation pathways. In particular, we discuss the role of matrix metalloproteinases in vascular remodelling concerning ischaemic stroke, brain haemorrhage, vascular dementia, carotid artery plaques and cerebral aneurysms. Copyright (c) 2005 S. Karger AG, Basel.Entities:
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Year: 2005 PMID: 16088108 DOI: 10.1159/000087197
Source DB: PubMed Journal: Cerebrovasc Dis ISSN: 1015-9770 Impact factor: 2.762