BACKGROUND: Serotonin (5-hydroxytryptamine; 5-HT) is a key mediator in the control of food intake and is probably involved in the etiology of anorexia nervosa. An association between a polymorphism of the 5-HT receptor (5-HT2A) gene promoter (-1438G/A) and anorexia nervosa has been reported. OBJECTIVE: We investigated the relation between the -1438G/A polymorphism of the 5-HT(2A) gene and the energy and macronutrient intakes of children and adolescents. DESIGN: This cross-sectional study included 370 children and adolescents aged 10-20 y (176 boys and 194 girls from 251 families) drawn from the Stanislas Family Study. Energy and macronutrient intakes were assessed by using 3-d food records. The -1438G/A polymorphism was analyzed by polymerase chain reaction and then by Hpa II digestion. RESULTS: In the overall group, after adjustment for age, sex, weight, height, and family correlation, the A allele was significantly associated with lower energy (P for trend = 0.045) and with total, monounsaturated, and saturated fat intakes expressed in g/d (P for trend = 0.007, 0.005, and 0.006, respectively). Subjects with the GA genotype had intermediate values. In addition, genotype x sex and genotype x age interactions were not significant. CONCLUSIONS: The 5-HT2A gene polymorphism in the promoter region is associated with energy and fat intakes in young people. This could be explained by the role of the serotonergic system as a determinant of food intakes and eating behavior.
BACKGROUND:Serotonin (5-hydroxytryptamine; 5-HT) is a key mediator in the control of food intake and is probably involved in the etiology of anorexia nervosa. An association between a polymorphism of the 5-HT receptor (5-HT2A) gene promoter (-1438G/A) and anorexia nervosa has been reported. OBJECTIVE: We investigated the relation between the -1438G/A polymorphism of the 5-HT(2A) gene and the energy and macronutrient intakes of children and adolescents. DESIGN: This cross-sectional study included 370 children and adolescents aged 10-20 y (176 boys and 194 girls from 251 families) drawn from the Stanislas Family Study. Energy and macronutrient intakes were assessed by using 3-d food records. The -1438G/A polymorphism was analyzed by polymerase chain reaction and then by Hpa II digestion. RESULTS: In the overall group, after adjustment for age, sex, weight, height, and family correlation, the A allele was significantly associated with lower energy (P for trend = 0.045) and with total, monounsaturated, and saturated fat intakes expressed in g/d (P for trend = 0.007, 0.005, and 0.006, respectively). Subjects with the GA genotype had intermediate values. In addition, genotype x sex and genotype x age interactions were not significant. CONCLUSIONS: The 5-HT2A gene polymorphism in the promoter region is associated with energy and fat intakes in young people. This could be explained by the role of the serotonergic system as a determinant of food intakes and eating behavior.
Authors: Rachel Koren; Alexis E Duncan; Melissa A Munn-Chernoff; Kathleen K Bucholz; Michael T Lynskey; Andrew C Heath; Arpana Agrawal Journal: Psychiatr Genet Date: 2014-02 Impact factor: 2.458
Authors: Bernard F Fuemmeler; Tanya D Agurs-Collins; F Joseph McClernon; Scott H Kollins; Melanie E Kail; Andrew W Bergen; Allison E Ashley-Koch Journal: Obesity (Silver Spring) Date: 2008-02 Impact factor: 5.002
Authors: Toshiko Tanaka; Julius S Ngwa; Frank J A van Rooij; M Carola Zillikens; Mary K Wojczynski; Alexis C Frazier-Wood; Denise K Houston; Stavroula Kanoni; Rozenn N Lemaitre; Jian'an Luan; Vera Mikkilä; Frida Renstrom; Emily Sonestedt; Jing Hua Zhao; Audrey Y Chu; Lu Qi; Daniel I Chasman; Marcia C de Oliveira Otto; Emily J Dhurandhar; Mary F Feitosa; Ingegerd Johansson; Kay-Tee Khaw; Kurt K Lohman; Ani Manichaikul; Nicola M McKeown; Dariush Mozaffarian; Andrew Singleton; Kathleen Stirrups; Jorma Viikari; Zheng Ye; Stefania Bandinelli; Inês Barroso; Panos Deloukas; Nita G Forouhi; Albert Hofman; Yongmei Liu; Leo-Pekka Lyytikäinen; Kari E North; Maria Dimitriou; Goran Hallmans; Mika Kähönen; Claudia Langenberg; Jose M Ordovas; André G Uitterlinden; Frank B Hu; Ioanna-Panagiota Kalafati; Olli Raitakari; Oscar H Franco; Andrew Johnson; Valur Emilsson; Jennifer A Schrack; Richard D Semba; David S Siscovick; Donna K Arnett; Ingrid B Borecki; Paul W Franks; Stephen B Kritchevsky; Terho Lehtimäki; Ruth J F Loos; Marju Orho-Melander; Jerome I Rotter; Nicholas J Wareham; Jacqueline C M Witteman; Luigi Ferrucci; George Dedoussis; L Adrienne Cupples; Jennifer A Nettleton Journal: Am J Clin Nutr Date: 2013-05-01 Impact factor: 7.045
Authors: Jana V van Vliet-Ostaptchouk; N Charlotte Onland-Moret; Ronit Shiri-Sverdlov; Patrick J J van Gorp; Anne Custers; Petra H M Peeters; Cisca Wijmenga; Marten H Hofker; Yvonne T van der Schouw Journal: PLoS One Date: 2008-01-09 Impact factor: 3.240