| Literature DB >> 16087335 |
Namrata Dwivedi1, Neetu Tewari, V K Tiwari, Vinita Chaturvedi, Y K Manju, A Srivastava, A Giakwad, S Sinha, R P Tripathi.
Abstract
An efficient, high yield and one-pot synthesis of phenyl cyclopropyl methanones by reaction of different aryl alcohols with 4'-fluoro-4-chloro-butyrophenone in THF/DMF in the presence of NaH/TBAB is reported. Most of the methanones were further reduced to respective alcohols or methylenes. All the compounds were evaluated for their anti-tubercular activities against M. tuberculosis H37Rv in vitro displaying MICs ranging from 25 to 3.125 microg/mL. The most active compounds showed activity against MDR strains and two of them (14 and 16) showed marginal enhancement of MST in mice.Entities:
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Year: 2005 PMID： 16087335 DOI： 10.1016/j.bmcl.2005.07.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823