| Literature DB >> 16087332 |
A Arasappan1, F G Njoroge, T-Y Chan, F Bennett, S L Bogen, K Chen, H Gu, L Hong, E Jao, Y-T Liu, R G Lovey, T Parekh, R E Pike, P Pinto, B Santhanam, S Venkatraman, H Vaccaro, H Wang, X Yang, Z Zhu, B Mckittrick, A K Saksena, V Girijavallabhan, J Pichardo, N Butkiewicz, R Ingram, B Malcolm, A Prongay, N Yao, B Marten, V Madison, S Kemp, O Levy, M Lim-Wilby, S Tamura, A K Ganguly.
Abstract
We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P'2 moiety.Entities:
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Year: 2005 PMID： 16087332 DOI： 10.1016/j.bmcl.2005.06.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823