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Literature DB >> 16087327

MIC and other NKG2D ligands: from none to too many.

Seiamak Bahram¹, Hidetoshi Inoko, Takashi Shiina, Mirjana Radosavljevic.

Abstract

NKG2D, a prime activatory receptor on human NK, CD8(+) alphabeta and gammadelta cells, has a variety of ligands, which, despite sharing membership of the MHC class I structural club, display an array of unique features. Chronologically, human MIC molecules were the first NKG2D ligands to be identified. Then came RAET1 (ULBP) molecules, which were identified in both man and mouse, as well as H60 and MULT1, which have no counterparts in man to date. The question remains as to why, more than how, the evolutionary conserved, apparently monomorphic, single copy, NKG2D, can/should adapt to this variety of ligands, and when it does, what is the evolutionary advantage of this profusion of ligands for a single receptor?

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16087327 DOI： 10.1016/j.coi.2005.07.016

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

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Cited

30 in total

1. Association of major histocompatibility complex class 1 chain-related gene a dimorphism with type 1 diabetes and latent autoimmune diabetes in adults in the Algerian population.

Authors: Rachida Raache; Khadidja Belanteur; Habiba Amroun; Amel Benyahia; Amel Heniche; Malha Azzouz; Safia Mimouni; Thibaud Gervais; Dominique Latinne; Aissa Boudiba; Nabila Attal; Mohamed Cherif Abbadi
Journal: Clin Vaccine Immunol Date: 2012-02-08

2. Genomic location and characterisation of MIC genes in cattle.

Authors: James Birch; Cristina De Juan Sanjuan; Efrain Guzman; Shirley A Ellis
Journal: Immunogenetics Date: 2008-06-12 Impact factor: 2.846

3. Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses.

Authors: Roberto Biassoni; Elisabetta Ugolotti; Andrea De Maria
Journal: Self Nonself Date: 2010-03-06

4. Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity.

Authors: Anastasia Shibina; Diana Seidel; Srinivas S Somanchi; Dean A Lee; Alexander Stermann; Barry J Maurer; Holger N Lode; C Patrick Reynolds; Nicole Huebener
Journal: J Mol Med (Berl) Date: 2012-09-30 Impact factor: 4.599

Review 5. Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.

Authors: Silvia M Vidal; Salim I Khakoo; Christine A Biron
Journal: Curr Opin Virol Date: 2011-12 Impact factor: 7.090

10. High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC.

Authors: Sally L Rogers; Jim Kaufman
Journal: Immunogenetics Date: 2008-06-24 Impact factor: 2.846

MIC and other NKG2D ligands: from none to too many.

1. Association of major histocompatibility complex class 1 chain-related gene a dimorphism with type 1 diabetes and latent autoimmune diabetes in adults in the Algerian population.

2. Genomic location and characterisation of MIC genes in cattle.

3. Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses.

4. Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity.

Review 5. Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.

6. Enhanced activation of human NK cells by drug-exposed hepatocytes.

Review 7. Immunogenetics of the NKG2D ligand gene family.

8. MICA variant promotes allosensitization after kidney transplantation.

9. An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding.

10. High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC.