Literature DB >> 16086206

[Efficient killing of anthrax spores using aqueous and alcoholic peracetic acid solutions].

H Nattermann1, S Becker, D Jacob, S R Klee, I Schwebke, B Appel.   

Abstract

We analysed the sporicidal effect of different concentrations of aqueous and alcoholic peracetic acid (PAA) solutions on anthrax spores in suspension and germ carrier tests. In activation of anthrax spores in suspension assays was achieved in less than 2 min using 1% PAA solution and in less than 3 min using 0.5% PAA solution, respectively. In contrast, in germ carrier as says, a test under practical conditions, spores on 38% of the germ carriers survived treatment with 1% PAA solution for 15 min. The use of PAA in 80% ethyl alcohol outclassed the sporicidal effect of aqueous PAA solutions in both suspension and germ carrier assays. Anthrax spores on 14% of germ carriers tested survived 30 min of treatment with a 1% aqueous PAA solution. In contrast anthrax spores were reliably inactivated under the same test procedure using a 1% alcoholic PAA solution for 30 min. The proven enhancement of the sporicidal effect of alcoholic PAA solutions should be kept in mind when using disinfectants in practice. In further surveys we will optimise the test conditions.

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Year:  2005        PMID: 16086206     DOI: 10.1007/s00103-005-1108-4

Source DB:  PubMed          Journal:  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz        ISSN: 1436-9990            Impact factor:   1.513


  3 in total

Review 1.  Decontamination of high-risk animal and zoonotic pathogens.

Authors:  Hendrik Frentzel; Andrea Menrath; Katharina Tomuzia; Juliane Braeunig; Bernd Appel
Journal:  Biosecur Bioterror       Date:  2013-09

2.  Influence of temperature and organic load on chemical disinfection of Geobacillus steareothermophilus spores, a surrogate for Bacillus anthracis.

Authors:  Jiewen Guan; Maria Chan; Brian W Brooks; Liz Rohonczy
Journal:  Can J Vet Res       Date:  2013-04       Impact factor: 1.310

3.  A Cumulative Spore Killing Approach: Synergistic Sporicidal Activity of Dilute Peracetic Acid and Ethanol at Low pH Against Clostridium difficile and Bacillus subtilis Spores.

Authors:  Michelle M Nerandzic; Thriveen Sankar C; Peter Setlow; Curtis J Donskey
Journal:  Open Forum Infect Dis       Date:  2015-12-22       Impact factor: 3.835

  3 in total

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