Literature DB >> 1608599

L-ascorbic acid 2-phosphate enhances the production of type I and type III collagen peptides in cultured rabbit keratocytes.

S Saika1, K Uenoyama, K Hiroi, A Ooshima.   

Abstract

We studied the effect of L-ascorbic acid 2-phosphate (P-Asc), a long-acting phosphate derivative of L-ascorbic acid, on the production and secretion of type I and type III collagen peptides in cultured rabbit keratocytes using immunohistochemistry and enzyme immunoassay. P-Asc enhanced production and secretion of these collagen peptides. Our observations support a therapeutic role for P-Asc in the repair of corneal stromal damage such as caused by corneal chemical burn.

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Year:  1992        PMID： 1608599     DOI： 10.1159/000267149

Source DB:  PubMed          Journal:  Ophthalmic Res        ISSN： 0030-3747            Impact factor:   2.892


  11 in total

1.  Immunolocalization of prolyl 4-hydroxylase in fibroblasts cultured from Tenon's capsule of humans.

Authors:  S Saika; A Ooshima; O Yamanaka; O Tonoe; Y Okada; Y Ohnishi; M Kimura
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-04       Impact factor: 3.117

2.  Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro.

Authors:  S Saika; A Ooshima; O Yamanaka; Y Okada; S Tanaka; Y Ohnishi
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-08       Impact factor: 3.117

3.  Deposition of extracellular matrix on intraocular lenses in rabbits: an immunohistochemical and transmission electron microscopic study.

Authors:  S Saika; S Tanaka; S Ohmi; A Minamide; Y Ohnishi; A Yamanaka; A Ooshima; M Kimura
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1997-04       Impact factor: 3.117

4.  Deposition of extracellular matrix on silicone intraocular lens implants in rabbits.

Authors:  S Saika; S Ohmi; A Ooshima; M Kimura; S Tanaka; Y Okada; Y Ohnishi; A Yamanaka
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1997-08       Impact factor: 3.117

5.  Ascorbic acid phosphate ester and wound healing in rabbit corneal alkali burns: epithelial basement membrane and stroma.

Authors:  S Saika; K Uenoyama; K Hiroi; H Tanioka; K Takase; M Hikita
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1993-04       Impact factor: 3.117

6.  Human corneal fibrosis: an in vitro model.

Authors:  Dimitris Karamichos; Xiaoqing Q Guo; Audrey E K Hutcheon; James D Zieske
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-10-29       Impact factor: 4.799

7.  Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts.

Authors:  Xiaoqing Guo; Audrey E K Hutcheon; Suzanna A Melotti; James D Zieske; Vickery Trinkaus-Randall; Jeffrey W Ruberti
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-09       Impact factor: 4.799

8.  Effect of lysyl hydroxylase inhibitor, minoxidil, on ultrastructure and behavior of cultured rabbit subconjunctival fibroblasts.

Authors:  S Saika; A Ooshima; N Hashizume; O Yamanaka; S Tanaka; Y Okada; S Kobata
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1995-06       Impact factor: 3.117

9.  Characterizing the effects of VPA, VC and RCCS on rabbit keratocytes onto decellularized bovine cornea.

Authors:  Ying Dai; Jiansu Chen; Hongyang Li; Shanyi Li; Jian Chen; Yong Ding; Jing Wu; Chan Wang; Meihua Tan
Journal:  PLoS One       Date:  2012-11-29       Impact factor: 3.240

10.  Ascorbic acid promotes a TGFβ1-induced myofibroblast phenotype switch.

Authors:  Bram Piersma; Olaf Y Wouters; Saskia de Rond; Miriam Boersema; Rutger A F Gjaltema; Ruud A Bank
Journal:  Physiol Rep       Date:  2017-09
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